Tracking mitochondrial 1 O 2 -ROS production through a differential mitochondria-nucleoli fluorescent probe

The dual-emissive fluorescent probe described here enabled dynamic tracking of singlet oxygen (1O2)-ROS species production and localization dynamics between the mitochondria and nucleoli in the presence of agents perturbing the mitochondrial membrane potential and under a photodynamic (PDT) system....

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018-12, Vol.54 (99), p.13997-14000
Main Authors: Flores-Cruz, Ricardo, Jiménez-Sánchez, Arturo
Format: Article
Language:English
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Summary:The dual-emissive fluorescent probe described here enabled dynamic tracking of singlet oxygen (1O2)-ROS species production and localization dynamics between the mitochondria and nucleoli in the presence of agents perturbing the mitochondrial membrane potential and under a photodynamic (PDT) system. Local structural information during the probe-1O2 interaction was followed by spectrally resolved confocal microscopy.
ISSN:1359-7345
1364-548X
DOI:10.1039/C8CC08289H