Fading of 5‐HT 4 receptor‐mediated inotropic responses to 5‐hydroxytryptamine is caused by phosphodiesterase activity in porcine atrium

Inotropic responses to 5‐hydroxytryptamine (5‐HT) in human and porcine atrium can fade, suggesting 5‐HT 4 receptor desensitization. De Maeyer et al ., however, show in this issue that inhibition of phosphodiesterases with isobutyl‐methyl‐xanthine prevents fading of 5‐HT 4 receptor‐mediated responses...

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Published in:British journal of pharmacology 2009-01, Vol.147 (2), p.128-130
Main Authors: Kaumann, Alberto J, Levy, Finn Olav
Format: Article
Language:English
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Summary:Inotropic responses to 5‐hydroxytryptamine (5‐HT) in human and porcine atrium can fade, suggesting 5‐HT 4 receptor desensitization. De Maeyer et al ., however, show in this issue that inhibition of phosphodiesterases with isobutyl‐methyl‐xanthine prevents fading of 5‐HT 4 receptor‐mediated responses to 5‐HT and the partial agonist prucalopride in porcine atrium. British Journal of Pharmacology (2006) 147 , 128–130. doi: 10.1038/sj.bjp.0706501
ISSN:0007-1188
1476-5381
DOI:10.1038/sj.bjp.0706501