Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals

This review showcases various coupling reagents which have been implemented specifically for large-scale amide synthesis via the condensation of an acid and amine, while highlighting the benefits and drawbacks of each reagent on an industrial scale.

Bibliographic Details

Published in:	Organic process research & development 2016-02, Vol.20 (2), p.140-177
Main Authors:	Dunetz, Joshua R, Magano, Javier, Weisenburger, Gerald A
Format:	Article
Language:	English
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Online Access:	Get full text
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