Development of an Efficient Process for the Preparation of Sch 39166:  Aziridinium Chemistry on Scale

A large-scale synthesis of a tricyclic D1/D5 dopamine antagonist based on regio- and stereoselective ring opening of an aziridinium ion with a Grignard reagent was optimized and scaled up.

Bibliographic Details

Published in:	Organic process research & development 2004-09, Vol.8 (5), p.754-768
Main Authors:	Gala, Dinesh, Dahanukar, Vilas H, Eckert, Jeffery M, Lucas, Brian S, Schumacher, Doris P, Zavialov, Ilia A, Buholzer, Patrik, Kubisch, Peter, Mergelsberg, Ingrid, Scherer, Dominik
Format:	Article
Language:	English
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