One-Pot Synthesis of Luotonin A and Its Analogues

Starting with inexpensive reagents, a self-directed chemical process with the aid of a single metal triflate was readily achieved to concomitantly construct quinazoline and pyrroloquinoline cores to afford the synthesis of luotonin A and its analogues. Among all compounds prepared, 2c, 2d, and 3b ex...

Full description

Saved in:
Bibliographic Details
Published in:Organic letters 2011-03, Vol.13 (5), p.920-923
Main Authors: Tseng, Ming-Chung, Chu, Yu-Wan, Tsai, Hsiang-Ping, Lin, Chun-Mao, Hwang, Jaulang, Chu, Yen-Ho
Format: Article
Language:English
Subjects:
DNA Topoisomerases, Type I - drug effects
Humans
Molecular Structure
Peganum - chemistry
Pyrroles - chemical synthesis
Pyrroles - chemistry
Pyrroles - pharmacology
Quinazolines - chemical synthesis
Quinazolines - chemistry
Quinazolines - pharmacology
Quinolines - chemical synthesis
Quinolines - chemistry
Quinolines - pharmacology
Quinones - chemical synthesis
Quinones - chemistry
Quinones - pharmacology
Topoisomerase I Inhibitors - chemical synthesis
Topoisomerase I Inhibitors - chemistry
Topoisomerase I Inhibitors - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Starting with inexpensive reagents, a self-directed chemical process with the aid of a single metal triflate was readily achieved to concomitantly construct quinazoline and pyrroloquinoline cores to afford the synthesis of luotonin A and its analogues. Among all compounds prepared, 2c, 2d, and 3b exhibit more potent inhibitory activity than luotonin A against human topoisomerase I.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol1029707