T 1 and T 2 Dual-Mode MRI Contrast Agent for Enhancing Accuracy by Engineered Nanomaterials

One of the holy grails in biomedical imaging technology is to achieve accurate imaging of biological targets. The development of sophisticated instrumentation and the use of contrast agents have improved the accuracy of biomedical imaging. However, the issue of false imaging remains a problem. Here,...

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Bibliographic Details
Published in:ACS nano 2014-04, Vol.8 (4), p.3393-3401
Main Authors: Shin, Tae-Hyun, Choi, Jin-sil, Yun, Seokhwan, Kim, Il-Sun, Song, Ho-Taek, Kim, Youngmee, Park, Kook In, Cheon, Jinwoo
Format: Article
Language:English
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Summary:One of the holy grails in biomedical imaging technology is to achieve accurate imaging of biological targets. The development of sophisticated instrumentation and the use of contrast agents have improved the accuracy of biomedical imaging. However, the issue of false imaging remains a problem. Here, we developed a dual-mode artifact filtering nanoparticle imaging agent (AFIA) that comprises a combination of paramagnetic and superparamagnetic nanomaterials. This AFIA has the ability to perform “AND logic gate” algorithm to eliminate false errors (artifacts) from the raw images to enhance accuracy of the MRI. We confirm the artifact filtering capability of AFIA in MRI phantoms and further demonstrate that artifact-free imaging of stem cell migration is possible in vivo.
ISSN:1936-0851
1936-086X
DOI:10.1021/nn405977t