Solid State and Solution Self-Assembly of Helical Polypeptides Tethered to Polyhedral Oligomeric Silsesquioxanes

New macromolecular self-assembling building blocks, polyhedral oligo- silsesquioxane (POSS)-helical polypeptide copolymers, have been synthesized through the ring-opening polymerization (ROP) of γ-benzyl-l-glutamate N-carboxyanhydride (γ-Bn-Glu NCA) using aminopropyl isobutyl-POSS as a macroinitiato...

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Bibliographic Details
Published in:Macromolecules 2009-03, Vol.42 (5), p.1619-1626
Main Authors: Kuo, Shiao-Wei, Lee, Hsin-Fang, Huang, Wu-Jang, Jeong, Kwang-Un, Chang, Feng-Chih
Format: Article
Language:English
Subjects:
Applied sciences
Exact sciences and technology
Inorganic and organomineral polymers
Physicochemistry of polymers
Preparation
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Summary:New macromolecular self-assembling building blocks, polyhedral oligo- silsesquioxane (POSS)-helical polypeptide copolymers, have been synthesized through the ring-opening polymerization (ROP) of γ-benzyl-l-glutamate N-carboxyanhydride (γ-Bn-Glu NCA) using aminopropyl isobutyl-POSS as a macroinitiator. The incorporation of POSS units at the chain ends of PBLG moieties has two important effects: allowing intramolecular hydrogen bonding between the POSS and PBLG units to enhance the latter’s α-helical conformations in the solid state and preventing the aggregation of nanoribbons through the POSS blocks’ protrusion from the ribbons to allow the formation of clear gels in solution.
ISSN:0024-9297
1520-5835
DOI:10.1021/ma802370y