Novel Benzophenones as Non-nucleoside Reverse Transcriptase Inhibitors of HIV-1

GW4511, GW4751, and GW3011 showed IC50 values ≤2 nM against wild type HIV-1 and

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Bibliographic Details
Published in:Journal of medicinal chemistry 2004-02, Vol.47 (5), p.1175-1182
Main Authors: Chan, Joseph H, Freeman, George A, Tidwell, Jeffrey H, Romines, Karen R, Schaller, Lee T, Cowan, Jill R, Gonzales, Steve S, Lowell, Gina S, Andrews, C. W, Reynolds, David J, St Clair, Marty, Hazen, Richard J, Ferris, Rob G, Creech, Katrina L, Roberts, Grace B, Short, Steven A, Weaver, Kurt, Koszalka, George W, Boone, Lawrence R
Format: Article
Language:English
Subjects:
Anti-HIV Agents - chemical synthesis
Anti-HIV Agents - chemistry
Anti-HIV Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Benzophenones - chemical synthesis
Benzophenones - chemistry
Benzophenones - pharmacology
Biological and medical sciences
Cell Line
Crystallography, X-Ray
Drug Resistance, Viral
HIV Reverse Transcriptase - antagonists & inhibitors
HIV Reverse Transcriptase - chemistry
HIV Reverse Transcriptase - metabolism
HIV-1 - drug effects
HIV-1 - enzymology
HIV-1 - genetics
Humans
Inhibitory Concentration 50
Medical sciences
Mutation
Pharmacology. Drug treatments
Protein Binding
Reverse Transcriptase Inhibitors - chemical synthesis
Reverse Transcriptase Inhibitors - chemistry
Reverse Transcriptase Inhibitors - pharmacology
Structure-Activity Relationship
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Description
Summary:GW4511, GW4751, and GW3011 showed IC50 values ≤2 nM against wild type HIV-1 and
ISSN:0022-2623
1520-4804
DOI:10.1021/jm030255y