Toxicity and Antioxidant Activity in Vitro and in Vivo of Two Fucus vesiculosus Extracts

The consumption of seaweeds has increased in recent years. However, their adverse and beneficial effects have scarcely been studied. Two extracts from the brown seaweed Fucus vesiculosus containing 28.8% polyphenols or 18% polyphenols plus 0.0012% fucoxanthin have been obtained and studied to determ...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2008-09, Vol.56 (17), p.7773-7780
Main Authors: Zaragozá, M. C, López, D, P. Sáiz, M, Poquet, M, Pérez, J, Puig-Parellada, P, Màrmol, F, Simonetti, P, Gardana, C, Lerat, Y, Burtin, P, Inisan, C, Rousseau, I, Besnard, M, Mitjavila, M. T
Format: Article
Language:English
Subjects:
Animals
antioxidant activity
Antioxidants - pharmacology
Bioactive Constituents
Biological and medical sciences
Cell Line
Erythrocytes - drug effects
Female
Flavonoids - analysis
Food industries
fucoxanthin
Fucus - chemistry
Fucus vesiculosus
Fundamental and applied biological sciences. Psychology
Macrophage Activation - drug effects
Macrophages - drug effects
Male
Mice
nitric oxide
oxidative stress
Phenols - analysis
phloroglucinol
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Extracts - toxicity
Polyphenols
Rats
Rats, Sprague-Dawley
superoxide anion
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Summary:The consumption of seaweeds has increased in recent years. However, their adverse and beneficial effects have scarcely been studied. Two extracts from the brown seaweed Fucus vesiculosus containing 28.8% polyphenols or 18% polyphenols plus 0.0012% fucoxanthin have been obtained and studied to determine their toxicity in mice and rats and also their antioxidant activity. Both extracts were shown to lack any relevant toxic effects in an acute toxicity test following a 4 week daily treatment in rats. The extracts exhibited antioxidant activity in noncellular systems and in activated RAW 264.7 macrophages, as well as in ex vivo assays in plasma and erythrocytes, after the 4 week treatment in rats. Our ex vivo results indicated that compounds from extract 2 may be more easily absorbed and that the antioxidants in their parent or metabolized form are more active. These findings support the view that the daily consumption of F. vesiculosus extract 2 (Healsea) would have potential benefits to humans.
ISSN:0021-8561
1520-5118
DOI:10.1021/jf8007053