Formation of Hemoglobin Adducts of Acrylamide after Its Ingestion in Rats Is Dependent on Age and Sex

The effect of fiber and fat contents of food and of age and sex of animals on the formation of hemoglobin adducts of acrylamide (AA-Hb) in blood has been studied. The results suggest that the absorption of acrylamide (AA) present in food is not affected by the fiber or fat contents of food. However,...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2008-07, Vol.56 (13), p.5096-5101
Main Authors: Sánchez, Juana, Cabrer, Joana M, Rosselló, Catalina A, Palou, Andreu, Picó, Catalina
Format: Article
Language:English
Subjects:
Acrylamide
Acrylamide - blood
Acrylamide - pharmacokinetics
Acrylamide - toxicity
acrylamides
age
Age Factors
animal age
animal models
Animals
bioavailability
Biological and medical sciences
Biological Availability
Carcinogens - pharmacokinetics
Carcinogens - toxicity
Chemical Aspects of Food Safety
Dietary Fiber - analysis
Eating
Fats - analysis
Feeding. Feeding behavior
Female
food
Food Analysis
Food industries
Food toxicology
Fundamental and applied biological sciences. Psychology
gender differences
hemoglobin
Hemoglobins - chemistry
ingestion
intestinal absorption
Male
Rats
Rats, Wistar
sex
Sex Factors
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:The effect of fiber and fat contents of food and of age and sex of animals on the formation of hemoglobin adducts of acrylamide (AA-Hb) in blood has been studied. The results suggest that the absorption of acrylamide (AA) present in food is not affected by the fiber or fat contents of food. However, AA-Hb resulting from the intake of an aqueous solution of AA is dependent on the age and sex of rats: AA-Hb levels were higher in females than in males (3.53- and 2.55-fold higher, respectively, for AA doses of 25 and 100 mg/kg) and in younger than in older rats (30.1% higher in 1.5 month old as compared to 14 month old rats). In males, AA-Hb levels found after the oral administration of AA in an aqueous solution were significantly lower than those found after dietary or intravenous administration. In conclusion, these results show the existence of significant differences in AA bioavailability from an aqueous solution depending on the sex and age of animals. If similar differences also occur in humans, they would be relevant to assess the exposure of different subpopulations to AA.
ISSN:0021-8561
1520-5118
DOI:10.1021/jf800171c