Sulfluramid Volatility Reduction by β-Cyclodextrin

Sulfluramid is an expensive active principle of insecticidal baits that is lost by volatilization during the pelletization of baits. To increase the thermal stability of sulfluramid, we tested its molecular encapsulation in β-cyclodextrin (β-CD), using molar ratios of 1:1 and 1:2 (sulfluramid:β-CD),...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2005-02, Vol.53 (4), p.1139-1143
Main Authors: Bergamasco, Rita de Cássia, Zanin, Gisella Maria, Moraes, Flavio Faria de
Format: Article
Language:English
Subjects:
baits
beta-Cyclodextrins - chemistry
Biological and medical sciences
Calorimetry, Differential Scanning
cyclodextrins
encapsulation
Fluorocarbons - chemistry
Fundamental and applied biological sciences. Psychology
Hot Temperature
insecticidal baits
insecticides
Medically important nuisances and vectors, pests of stored products and materials: population survey and control
Molecular Structure
Nuisances
organofluorine compounds
sulfluramid
Sulfonamides - chemistry
thermal stability
Thermogravimetry
Volatilization
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Summary:Sulfluramid is an expensive active principle of insecticidal baits that is lost by volatilization during the pelletization of baits. To increase the thermal stability of sulfluramid, we tested its molecular encapsulation in β-cyclodextrin (β-CD), using molar ratios of 1:1 and 1:2 (sulfluramid:β-CD), using the complex preparation techniques of coprecipitation and kneading. The physical mixture of sulfluramid and β-CD was also tested for comparison. The products of complexation were characterized by differential scanning calorimetry, thermogravimetry, and derivative thermogravimetry, indicating the formation of a sulfluramid/β-CD complex and showing that the release of the complexed sulfluramid occurs in the range of 270−300 °C, a temperature range that is well above the temperature at which sulfluramid sublimates (40 °C). This result warrants a reduced sulfluramid loss in the preparation of insecticidal baits. The preparation of the complex by kneading with molar ratio of 1:2 gave the highest yield of complex, about 64%, in relation to the theoretical maximum. Keywords: Sulfluramid; β-cyclodextrin; inclusion complex; DSC; TGA
ISSN:0021-8561
1520-5118
DOI:10.1021/jf0486747