Alteration of egg yolk cholesterol content and plasma lipoprotein profiles following administration of a totally synthetic HMG-CoA reductase inhibitor to laying hens

PD 123244-15 [(+/-)-(R*,R*)-3,4-dibromo-beta,delta-dihydroxy-2-(4-fluor ophenyl)-5-(1-methylethyl)-1H-pyrrol-1-heptanoic acid, sodium salt], a totally synthetic HMG-CoA reductase inhibitor, was fed to laying hens at dietary levels of either 0, 0.0091, 0.0273, or 0.0819% for 20 days (experiment 1) or...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 1993-07, Vol.41 (7), p.1094-1101
Main Authors: Elkin, Robert G, Freed, Marisue B, Kieft, Karen A, Newton, Roger S
Format: Article
Language:English
Subjects:
Biological and medical sciences
CHOLESTEROL
COLESTEROL
Egg and egg product industries
Food industries
Fundamental and applied biological sciences. Psychology
INHIBIDORES DE ENZIMAS
INHIBITEUR D'ENZYME
LIPOPROTEINAS
LIPOPROTEINE
METHODE D'APPLICATION
METODOS DE APLICACION
OXIDORREDUCTASAS
OXYDOREDUCTASE
PLASMA SANGUIN
PLASMA SANGUINEO
POLLO
POULET
VITELLUS
YEMA DE HUEVO
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Summary:PD 123244-15 [(+/-)-(R*,R*)-3,4-dibromo-beta,delta-dihydroxy-2-(4-fluor ophenyl)-5-(1-methylethyl)-1H-pyrrol-1-heptanoic acid, sodium salt], a totally synthetic HMG-CoA reductase inhibitor, was fed to laying hens at dietary levels of either 0, 0.0091, 0.0273, or 0.0819% for 20 days (experiment 1) or 0, 0.0273, 0.0546, or 0.0819% for 42 days (experiment 2). In each experiment, PD 123244-15 generally had little effect on egg or yolk weights, while hens fed 0.0819% PD 123244-15 produced fewer (P 0.05) eggs than the other three groups. Egg cholesterol contents varied inversely with the amount of dietary PD 123244-15, with a maximum reduction of approximately 30% obtained at the highest drug level in both experiments. With the exception of samples from hens fed 0.0091% PD 123244-15, plasma total cholesterol and triglyceride concentrations also varied inversely with the dietary amount of PD 123244-15. Further analysis of the plasma samples by high-performance gel permeation chromatography revealed that the PD 123244-15-mediated lowering of total cholesterol and triglycerides was almost totally accounted for by a reduction in the VLDL fraction. On the basis of reversed-phase HPLC analysis, no drug residues were detected in egg yolk and albumen extracts from hens fed 0.0819% PD 123244-15
ISSN:0021-8561
1520-5118
DOI:10.1021/jf00031a016