Sulfamethazine and its metabolites in pork: effects of cooking and gastrointestinal absorption of residues

Cooking-related changes in residues of [14C] sulfamethazine (SMZ) and its metabolites were measured in pork products obtained from an animal given a single dose of the drug. In addition, the gastrointestinal absorption of residues after ingestion of cooked pork by dogs was assessed by analysis of bl...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 1992-09, Vol.40 (9), p.1677-1682
Main Authors: Fischer, Lawrence J, Thulin, Andrew J, Zabik, Mary E, Booren, Alden M, Poppenga, Robert H, Chapman, Kena J
Format: Article
Language:English
Subjects:
ABSORCION DIGESTIVA
ABSORPTION DIGESTIVE
Agriculture
Agriculture, Multidisciplinary
Biological and medical sciences
CARNE DE CERDO
Chemistry
Chemistry, Applied
COCCION
CUISSON
Food industries
Food Science & Technology
Fundamental and applied biological sciences. Psychology
Life Sciences & Biomedicine
Meat and meat product industries
MEDICAMENT
MEDICAMENTOS
METABOLITE
METABOLITOS
Physical Sciences
RESIDU
RESIDUOS
Science & Technology
SULFAMIDE
SULFONAMIDAS
VIANDE PORCINE
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Summary:Cooking-related changes in residues of [14C] sulfamethazine (SMZ) and its metabolites were measured in pork products obtained from an animal given a single dose of the drug. In addition, the gastrointestinal absorption of residues after ingestion of cooked pork by dogs was assessed by analysis of blood and urine for SMZ and its metabolites. No loss of SMZ could be detected in pork loin, liver, and cured ham as a result of cooking by various methods. Levels of the N4-acetyl metabolite of SMZ were not altered by cooking but the N4-glucoside metabolite exhibited cooking-related declines of up to 70%. Liver, which contained high concentrations of the glucoside, exhibited an increase in SMZ as a result of cooking, and this could be explained by heat-related hydrolysis of SMZ-glucoside. Analysis of dog serum indicated slow but complete absorption of SMZ present in meat. Urine analysis showed the N-acetyl metabolite was also absorbed. The results indicate that cooking does not destroy and may increase SMZ in pork products and that ingestion of cooked pork can result in the absorption of drug and metabolite residues
ISSN:0021-8561
1520-5118
DOI:10.1021/jf00021a039