Spectroscopic Determination of Acid Dissociation Constants of Some Novel Drug Precursor 6-Acylbenzothiazolon Derivatives

The acid dissociation constants, as pK a values, of eight drug precursor 6-acylbenzothiazolon derivatives were determined using UV−vis spectroscopic technique. The protonation and deprotonation behaviors of the investigated molecules were studied from super basic to super acid regions (i.e., 8 mol·L...

Full description

Saved in:
Bibliographic Details
Published in:Journal of chemical and engineering data 2010-11, Vol.55 (11), p.4752-4756
Main Authors: Sıdır, Yadigar Gülseven, Sıdır, İsa, Berber, Halil, Taşal, Erol, Öğretir, Cemil
Format: Article
Language:English
Subjects:
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms
Organic chemistry
Preparations and properties
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The acid dissociation constants, as pK a values, of eight drug precursor 6-acylbenzothiazolon derivatives were determined using UV−vis spectroscopic technique. The protonation and deprotonation behaviors of the investigated molecules were studied from super basic to super acid regions (i.e., 8 mol·L−1 KOH to 98 % H2SO4) including the pH region. It was observed that protonation occurs only at the amid group in the super acid region. By validating the obtained acid dissociation constants, elucidation of the structure and protonation mechanisms of the studied molecules was attempted.
ISSN:0021-9568
1520-5134
DOI:10.1021/je100378t