A New Property of MCM-41:  Drug Delivery System

A new application of MCM-41 mesoporous materials has been developed. Two kinds of surfactants, C16TAB and C12TAB, have been employed to get different pore sizes. The samples were disk-shaped conformed before and after charging with ibuprofen, an anti-inflammatory drug. In all the cases the weight pe...

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Bibliographic Details
Published in:Chemistry of materials 2001-02, Vol.13 (2), p.308-311
Main Authors: Vallet-Regi, M, Rámila, A, del Real, R. P, Pérez-Pariente, J
Format: Article
Language:English
Subjects:
Biological and medical sciences
General pharmacology
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
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Summary:A new application of MCM-41 mesoporous materials has been developed. Two kinds of surfactants, C16TAB and C12TAB, have been employed to get different pore sizes. The samples were disk-shaped conformed before and after charging with ibuprofen, an anti-inflammatory drug. In all the cases the weight percent ratio of drug/MCM-41 was 30%. The drug release plots show a different behavior depending on the method for charging the drug in the material but not on the employed surfactant.
ISSN:0897-4756
1520-5002
DOI:10.1021/cm0011559