Semiconducting Polymer Nanoparticles as Theranostic System for Near-Infrared-II Fluorescence Imaging and Photothermal Therapy under Safe Laser Fluence

Theranostic systems combining fluorescence imaging in the second near-infrared window (NIR-II, 1000–1700 nm) and photothermal therapy (PTT) under safe laser fluence have great potential in preclinical research and clinical practice, but the development of such systems with sufficient effective NIR-I...

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Bibliographic Details
Published in:ACS nano 2020-02, Vol.14 (2), p.2509-2521
Main Authors: Yang, Yanqing, Fan, Xiaoxiao, Li, Ling, Yang, Yuming, Nuernisha, Alifu, Xue, Dingwei, He, Chao, Qian, Jun, Hu, Qinglian, Chen, Hao, Liu, Jie, Huang, Wei
Format: Article
Language:English
Subjects:
Animals
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - therapy
Cell Line, Tumor
Fluorescent Dyes - chemistry
Infrared Rays
Ischemic Stroke - diagnostic imaging
Ischemic Stroke - therapy
Lasers
Mice
Mice, Inbred ICR
Nanoparticles - chemistry
Optical Imaging
Particle Size
Photothermal Therapy
Polymers - chemistry
Semiconductors
Surface Properties
Theranostic Nanomedicine
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Summary:Theranostic systems combining fluorescence imaging in the second near-infrared window (NIR-II, 1000–1700 nm) and photothermal therapy (PTT) under safe laser fluence have great potential in preclinical research and clinical practice, but the development of such systems with sufficient effective NIR-II brightness and excellent photothermal properties is still challenging. Here we report a theranostic system based on semiconducting polymer nanoparticles (L1057 NPs) for NIR-II fluorescence imaging and PTT under a 980 nm laser irradiation, with low (25 mW/cm2) and high (720 mW/cm2) laser fluence, respectively. Taking into consideration multiple parameters including the extinction coefficient, the quantum yield, and the portion of emission in the NIR-II region, L1057 NPs have much higher effective NIR-II brightness than most reported organic NIR-II fluorophores. The high brightness, together with good stability and excellent biocompatibility, allows for real-time visualization of the whole body and brain vessels and the detection of cerebral ischemic stroke and tumors with high clarity. The excellent photothermal properties and high maximal permissible exposure limit at 980 nm allow L1057 NPs for PTT of tumors under safe laser fluence. This study demonstrates that L1057 NPs behave as an excellent theranostic system for NIR-II imaging and PTT under safe laser fluence and have great potential for a wide range of biomedical applications.
ISSN:1936-0851
1936-086X
DOI:10.1021/acsnano.0c00043