Nickel-Catalyzed Deamidative Step-Down Reduction of Amides to Aromatic Hydrocarbons

To date, cleavage of the C−N bond in aromatic amides has been achieved in molecules with a distorted constitutional framework around the nitrogen atom. In this report, a nickel-catalyzed reduction of planar amides to the corresponding lower hydrocarbon homologue has been reported. This involves a on...

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Bibliographic Details
Published in:ACS catalysis 2017-01, Vol.7 (1), p.433-437
Main Authors: Dey, Aniruddha, Sasmal, Sheuli, Seth, Kapileswar, Lahiri, Goutam Kumar, Maiti, Debabrata
Format: Article
Language:English
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Summary:To date, cleavage of the C−N bond in aromatic amides has been achieved in molecules with a distorted constitutional framework around the nitrogen atom. In this report, a nickel-catalyzed reduction of planar amides to the corresponding lower hydrocarbon homologue has been reported. This involves a one-pot reductive cleavage of the C−N bond followed by a tandem C−CO bond break in the presence of a hydride source. Substrate scope circumscribes deamidation examples which proceed via oxidative addition of nickel in the amide bonds of nontwisted amides. Mechanistic studies involving isolation and characterization of involved intermediates via different spectroscopic techniques reveal a deeper introspection into the plausible catalytic cycle for the methodology.
ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.6b03040