Adsorption of Porphyrin in Orthogonally Stacked Mesoporous Silica Films: Implications for Surface Modification of Biomedical Polyimide

An oriented cylindrical mesoporous silica (MPS) film has been synthesized on rubbing-treated (rubbed) polyimide (PI), which has the potential to be used as a surface-modified technology for biomedical catheters. However, the oriented cylindrical MPS film lacked isotropic mechanical properties becaus...

Full description

Saved in:
Bibliographic Details
Published in:ACS applied nano materials 2023-08, Vol.6 (15), p.14267-14277
Main Authors: Nakajima, Rin, Chai, Yadong, Endo, Aoi, Zhou, Yanni, Tagaya, Motohiro
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An oriented cylindrical mesoporous silica (MPS) film has been synthesized on rubbing-treated (rubbed) polyimide (PI), which has the potential to be used as a surface-modified technology for biomedical catheters. However, the oriented cylindrical MPS film lacked isotropic mechanical properties because the cylindrical mesostructures were uniaxially oriented. Thus, it is possible to improve the isotropic properties of cylindrical MPS films by cross-laminating their cylindrical mesostructure. In this study, an orthogonally stacked and cylindrically oriented MPS film with two layers (2-L-MPS) was successfully synthesized through the following processes: (i) The 1st-layer-oriented MPS film was synthesized on the 1st-layer-rubbed PI film. (ii) The 2nd-layer-rubbed PI film was coated on the 1st-layer-oriented MPS film where the rubbing direction was perpendicular to that of the 1st-layer-rubbed PI film. (iii) The 2nd-layer-oriented MPS film was synthesized on the 2nd-layer-rubbed PI film. As for the 2-L-MPS film, it was proved that the orthogonally stacked and cylindrically oriented MPS film with 2-layer from the φ-scan XRD patterns, and the pore diameters of the 1st- and 2nd-layer-oriented MPS films were 3.7 and 4.8 nm from the Barrett–Joyner–Halenda (BJH) pore size distributions. The isotropic mechanical property of the 2-L-MPS film is thought to be enhanced by orthogonal stacking. Subsequently, the 2-L-MPS films were immersed into α,β,γ,δ-tetrakis­(1-methylpyridinium-4-yl)­porphyrin p-toluenesulfonate (TMPyP) solutions with different concentrations, and the structures of the immersed 2-L-MPS films were evaluated and the adsorption states of TMPyP were investigated. The mesostructures of the 2-L-MPS films were still maintained after being immersed in the TMPyP solutions. Moreover, 2-L-MPS showed the different molecular adsorption states of TMPyP at the 1st- and 2nd-layer-oriented mesopores because of the difference in the pore size between each MPS layer. In the future, it is expected to be applied as a surface modification technology to endue biomedical materials such as PI catheters with excellent mechanical properties and oriented cell adhesion properties. Moreover, it has the potential to be used as a coating material that loads two drug molecules with different molecular diameters and releases them in a sustained manner by utilizing the difference in the pore size between the 1st- and 2nd-layer-oriented mesopores.
ISSN:2574-0970
2574-0970
DOI:10.1021/acsanm.3c02224