Near-Infrared-Activated Lysosome Pathway Death Induced by ROS Generated from Layered Double Hydroxide-Copper Sulfide Nanocomposites

The overdeveloped lysosomes in cancer cells are gaining increasing attention toward more precise and effective organelle-targeted cancer therapy. It is suggested that rod/plate-like nanomaterials with an appropriate size exhibited a greater quantity and longer-term lysosomal enrichment, as the shape...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2020-09, Vol.12 (36), p.40673-40683
Main Authors: Liu, Chen-Guang, Tang, Han-Xiao, Zheng, Xiang, Yang, Da-Yun, Zhang, Yang, Zhang, Jian-Ting, Kankala, Ranjith Kumar, Wang, Shi-Bin, Liu, Gang, Chen, Ai-Zheng
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - metabolism
Antineoplastic Agents - pharmacology
Cell Death - drug effects
Cell Membrane Permeability - drug effects
Cells, Cultured
Copper - chemistry
Copper - metabolism
Copper - pharmacology
Disease Models, Animal
Drug Screening Assays, Antitumor
Female
Functional Nanostructured Materials (including low-D carbon)
Humans
Hydroxides - chemistry
Hydroxides - metabolism
Hydroxides - pharmacology
Infrared Rays
Lysosomes - chemistry
Lysosomes - metabolism
Mammary Neoplasms, Experimental - diagnostic imaging
Mammary Neoplasms, Experimental - drug therapy
Mammary Neoplasms, Experimental - metabolism
Mice
Mice, Nude
Nanocomposites - chemistry
Particle Size
Photoacoustic Techniques
Photothermal Therapy
Reactive Oxygen Species - metabolism
Surface Properties
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Summary:The overdeveloped lysosomes in cancer cells are gaining increasing attention toward more precise and effective organelle-targeted cancer therapy. It is suggested that rod/plate-like nanomaterials with an appropriate size exhibited a greater quantity and longer-term lysosomal enrichment, as the shape plays a notable role in the nanomaterial transmembrane process and subcellular behaviors. Herein, a biodegradable platform based on layered double hydroxide-copper sulfide nanocomposites (LDH-CuS NCs) is successfully prepared via in situ growth of CuS nanodots on LDH nanoplates. The as-prepared LDH-CuS NCs exhibited not only high photothermal conversion and near-infrared (NIR)-induced chemodynamic and photodynamic therapeutic efficacies, but also could achieve real-time in vivo photoacoustic imaging (PAI) of the entire tumor. LDH-CuS NCs accumulated in lysosomes would then generate extensive subcellular reactive oxygen species (ROS) in situ, leading to lysosomal membrane permeabilization (LMP) pathway-associated cell death both in vitro and in vivo.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.0c11739