Effective Phototheranostics of Brain Tumor Assisted by Near-Infrared-II Light-Responsive Semiconducting Polymer Nanoparticles

Precise diagnosis and effective treatment of gliomas still remain a huge challenge. Photoacoustic-guided photothermal therapy (PTT) has unique advantages over conventional techniques for brain tumor theranostics, but existing nanoagents for photoacoustic imaging (PAI)-guided PTT are mainly organic s...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2020-07, Vol.12 (30), p.33492-33499
Main Authors: Wen, Guohua, Li, Xiaozhen, Zhang, Yachao, Han, Xiongqi, Xu, Xiayi, Liu, Chao, Chan, Kannie W. Y, Lee, Chun-Sing, Yin, Chao, Bian, Liming, Wang, Lidai
Format: Article
Language:English
Subjects:
Animals
Biological and Medical Applications of Materials and Interfaces
Brain Neoplasms - drug therapy
Brain Neoplasms - pathology
Cell Line, Tumor
Cell Survival - drug effects
Humans
Infrared Rays
Mice
Mice, Inbred NOD
Mice, SCID
Nanoparticles - chemistry
Nanoparticles - therapeutic use
Nanoparticles - toxicity
Photothermal Therapy
Polymers - chemistry
Semiconductors
Theranostic Nanomedicine
Transplantation, Heterologous
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Summary:Precise diagnosis and effective treatment of gliomas still remain a huge challenge. Photoacoustic-guided photothermal therapy (PTT) has unique advantages over conventional techniques for brain tumor theranostics, but existing nanoagents for photoacoustic imaging (PAI)-guided PTT are mainly organic small molecules or inorganic nanoparticles, which have the limitations of poor photostability and biocompatibility. Besides, the restricted absorption in the first near-infrared window (NIR-I) of the most existing nanoagents compromises their effectiveness for deep tissue PAI and PTT. We herein develop novel semiconducting polymer nanoparticles (SPNs) that are strongly absorptive in the second NIR window (NIR-II) to alleviate these problems. With the merits of excellent photoacoustic and photothermal performance, high photostability, proper size, and low toxicity, SPNs not only show efficient cellular uptake for PAI and PTT toward U87 glioma cells but also demonstrate effective accumulation in both subcutaneous tumors and brain tumors upon intravenous injection, thereby realizing efficient PAI-guided PTT toward gliomas under NIR-II light irradiation.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.0c08562