Zinc Oxide Spherical-Shaped Nanostructures: Investigation of Surface Reactivity and Interactions with Microbial and Mammalian Cells

Two ZnO materials of spherical hierarchical morphologies, with hollow (ZnOHS) and solid cores (ZnOSS), were obtained through the hydrolysis of zinc acetylacetonate in 1,4-butanediol. The nature of the defects and surface reactivity for the two ZnO materials were investigated through photoluminescenc...

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Bibliographic Details
Published in:Langmuir 2018-11, Vol.34 (45), p.13638-13651
Main Authors: Visinescu, Diana, Hussien, Mohammed Dyia, Moreno, Jose Calderon, Negrea, Raluca, Birjega, Ruxandra, Somacescu, Simona, Ene, Cristian D, Chifiriuc, Mariana Carmen, Popa, Marcela, Stan, Miruna S, Carp, Oana
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - toxicity
Candida albicans - drug effects
Cryptococcus neoformans - drug effects
Gram-Negative Bacteria - drug effects
Gram-Positive Bacteria - drug effects
Hep G2 Cells
Humans
Hydroxybutyrates - chemistry
Hydroxyl Radical - chemical synthesis
Microbial Sensitivity Tests
Nanostructures - chemistry
Nanostructures - toxicity
Pentanones - chemistry
Singlet Oxygen - chemistry
Zinc Oxide - chemical synthesis
Zinc Oxide - chemistry
Zinc Oxide - pharmacology
Zinc Oxide - toxicity
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Summary:Two ZnO materials of spherical hierarchical morphologies, with hollow (ZnOHS) and solid cores (ZnOSS), were obtained through the hydrolysis of zinc acetylacetonate in 1,4-butanediol. The nature of the defects and surface reactivity for the two ZnO materials were investigated through photoluminescence, X-ray photoelectron spectroscopy, and electron paramagnetic resonance (EPR) spectroscopy proving the coexistence of shallow and deep defects and, also, the presence of polyol byproducts adsorbed on the outer layers of the ZnO samples. The EPR spectroscopy coupled with the spin-trapping technique showed that the surface of the ZnO samples generates reactive oxygen species (ROS) like hydroxyl (•OH) and singlet oxygen (1O2) as well as carbon-centered radicals. The ZnO materials exhibited a wide spectrum of antimicrobial activity, being active against Gram-positive, Gram-negative, and fungi strains, both in planktonic and, more importantly, adherent growth states. The decrease of antimicrobial efficiency in the presence of a ROS scavenger (mannitol) and the decrease of the cell viability with the ROS level suggest that one of the mechanisms that governs both the antimicrobial and cytotoxic activities on human liver cells is ROS-mediated. However, at active antimicrobial concentrations, the biocompatibility of the tested materials is very good.
ISSN:0743-7463
1520-5827
DOI:10.1021/acs.langmuir.8b02528