Manganese in the Diet: Bioaccessibility, Adequate Intake, and Neurotoxicological Effects

Manganese (Mn) is an essential element that participates in several biological processes. Mn serves as a cofactor for several enzymes, such as glutamine synthetase and oxidoreductases, that have an important role in the defense of the organisms against oxidative stress. The diet is the main source o...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2020-11, Vol.68 (46), p.12893-12903
Main Authors: Martins, Airton C, Krum, Bárbara Nunes, Queirós, Libânia, Tinkov, Alexey A, Skalny, Anatoly V, Bowman, Aaron B, Aschner, Michael
Format: Article
Language:English
Subjects:
Animals
Biological Availability
Brain - drug effects
Brain - metabolism
Diet
Humans
Manganese - metabolism
Manganese - toxicity
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Summary:Manganese (Mn) is an essential element that participates in several biological processes. Mn serves as a cofactor for several enzymes, such as glutamine synthetase and oxidoreductases, that have an important role in the defense of the organisms against oxidative stress. The diet is the main source of Mn intake for humans, and adequate daily intake levels for this metal change with age. Moreover, in higher amounts, Mn may be toxic, mainly to the brain. Here, we provide an overview of Mn occurrence in food, addressing its bioaccessibility and discussing the dietary standard and recommended intake of Mn consumption. In addition, we review some mechanisms underlying Mn-induced neurotoxicity.
ISSN:0021-8561
1520-5118
DOI:10.1021/acs.jafc.0c00641