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Widespread dispersion of the resistance element tet (B)::IS CR2 in XDR Acinetobacter baumannii isolates
SUMMARY Acinetobacter baumannii is a significant nosocomial pathogen often associated with extreme drug resistance (XDR). In Argentina, isolates of A. baumannii resistant to tetracyclines have accounted for more than 40% of drug-resistant isolates in some hospitals. We have previously reported the d...
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| Published in: | Epidemiology and infection 2016-05, Vol.144 (7), p.1574-1578 |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
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| Summary: | SUMMARY
Acinetobacter baumannii
is a significant nosocomial pathogen often associated with extreme drug resistance (XDR). In Argentina, isolates of
A. baumannii
resistant to tetracyclines have accounted for more than 40% of drug-resistant isolates in some hospitals. We have previously reported the dispersion of the
tet
(B) resistance element associated with the IS
CR2
transposase in epidemiologically unrelated
A. baumannii
isolates recovered from 1983 to 2011. This study extends this surveillance to 77 recent (2009–2013) XDR
A. baumannii
isolates with different levels of minocycline susceptibility. Isolates were examined by a pan-PCR assay, which showed six different amplification patterns, and specific PCRs were used for the confirmation of the the ΔIS
CR2-tet
(B)-
tet
(R)-IS
CR2
element. The
tet
(B) gene was present in 66 isolates and the IS
CR2
element in 68 isolates; the
tet
(B) gene was associated with IS
CR2
in all
tet
(B)-positive isolates. We conclude that this element is widespread in XDR
A. baumannii
isolates from Argentina and could be responsible for the emergence of tetracycline resistance in recent years. |
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| ISSN: | 0950-2688 1469-4409 |
| DOI: | 10.1017/S0950268815002897 |