High-frequency stimulation of the hippocampus protects against seizure activity and hippocampal neuronal apoptosis induced by kainic acid administration in macaques

Highlights • HFS of the macaque hippocampus markedly reduced KA-induced seizure activity. • HFS afforded marked protection against neuronal cell death following KA treatment. • HFS attenuated KA-induced changes in apoptosis-related proteins.

Bibliographic Details

Published in:	Neuroscience 2014-01, Vol.256, p.370-378
Main Authors:	Chen, N, Gao, Y, Yan, N, Liu, C, Zhang, J.-G, Xing, W.-M, Kong, D.-M, Meng, F.-G
Format:	Article
Language:	eng
Subjects:	Analysis of Variance Animals Apoptosis - drug effects Apoptosis - physiology bcl-2-Associated X Protein - metabolism Biological and medical sciences Biophysics Caspase 3 - metabolism Disease Models, Animal Electric Stimulation - methods Electroencephalography Excitatory Amino Acid Agonists - toxicity Fundamental and applied biological sciences. Psychology Hippocampus - pathology Hippocampus - physiology In Situ Nick-End Labeling Kainic Acid - toxicity Macaca Magnetic Resonance Imaging Male Neurology Neurons - drug effects Seizures - chemically induced Seizures - therapy Vertebrates: nervous system and sense organs
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