Exercise physiology: exercise hyperpnea

The classical view of proportional chemoreceptor feed-back (central; carotid-body) and neural feed-forward (central command; muscle reflex) in controlling ventilation to regulate arterial PCO2 during exercise still has currency. However, control-system redundancy has led to several innovative scheme...

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Bibliographic Details
Published in:Current opinion in physiology 2019-08, Vol.10, p.166-172
Main Author: Ward, Susan A
Format: Article
Language:English
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Summary:The classical view of proportional chemoreceptor feed-back (central; carotid-body) and neural feed-forward (central command; muscle reflex) in controlling ventilation to regulate arterial PCO2 during exercise still has currency. However, control-system redundancy has led to several innovative schemes being proposed (e.g. optimization; plasticity; precedence; autocracy) which, while creative, require identification of physiological substrates. Impediments to convincing resolution include technical and interpretational limitations to isolating putative control mechanisms in intact exercising humans and the provision of animal equivalents to allow more invasive interventions. The insights provided by this review contribute to the knowledge base of human investigation, and introduce some novel and potentially exciting chemogenetic approaches in small animals. These should not lose sight, however, of the logical imperative to discriminate between robust control schemes that (a) integrate processes within plausible physiological equivalents, and (b) account for both the dynamic and steady-state system response over the entire range of exercise intensities.
ISSN:2468-8673
2468-8673
DOI:10.1016/j.cophys.2019.05.010