Application of generalized dispersion theory to vortex chromatography
•The impact of lateral acoustofluidic flow on Taylor dispersion was studied.•Generalized Dispersion theory was used to evaluate and predict Taylor dispersion.•The model was compared with experimental data.•The influence of aspect ratio and dimensions was studied. Acoustically induced secondary flows...
Saved in:
| Published in: | Journal of Chromatography A 2022-05, Vol.1670, p.462970, Article 462970 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | eng |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | •The impact of lateral acoustofluidic flow on Taylor dispersion was studied.•Generalized Dispersion theory was used to evaluate and predict Taylor dispersion.•The model was compared with experimental data.•The influence of aspect ratio and dimensions was studied.
Acoustically induced secondary flows are applied to enhance lateral mass transfer beyond the relatively slow diffusion. This has the goal to reduce convective axial dispersion and the resulting band broadening which, in turn, limits the performance of column chromatography. Traditional approaches based on Taylor-Aris model are limited to one-dimensional rectilinear (unidirectional) tube- or channel-flows. We therefore apply the generalized dispersion theory (GDT) allowing for prediction of the dependence of potentially improved performance on the characteristics of the induced secondary flow, channel geometry and solute properties as well as providing qualitative physical insight into the role of lateral flows. Results corroborate agreement with our experimental observations (residual standard deviation, Sres = 3.88) and demonstrate the advantage of applying GDT relative to 3D time-dependent simulations. |
|---|---|
| ISSN: | 0021-9673 |