Panthogenins A and B, two novel norergostanol steroids from Dioscorea panthaica

Two novel 27-norergostanol steroids, panthogenins A （1） and B （2）, possessing unusual rings E and F featuring a ketal moiety at C-25 were isolated from rhizomes ofDioscorea panthaica. Their structures and relative configurations were elucidated by extensive spectroscopic methods including 1D and 2D...

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Bibliographic Details
Published in:	Chinese chemical letters 2014-09, Vol.25 (9), p.1256-1258
Main Authors:	Shan, Xiao-Qing, Peng, Shu-Lin, Shi, Hai-Li, Wang, Xiao-Ling, Ding, Li-Sheng, Liao, Xun
Format:	Article
Language:	eng
Subjects:	Dioscorea panthaica Dioscoreaceae Insulin sensitizing activity NMR技术 Norergostanol steroids Structural elucidation X射线晶体学化合物增敏作用类固醇胰岛素谱方法黄山药
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Summary:	Two novel 27-norergostanol steroids, panthogenins A （1） and B （2）, possessing unusual rings E and F featuring a ketal moiety at C-25 were isolated from rhizomes ofDioscorea panthaica. Their structures and relative configurations were elucidated by extensive spectroscopic methods including 1D and 2D NMR techniques, and the structure of panthogenin A was further confirmed by X-ray crystallography. Both compounds showed potent in vitro insulin sensitizing activity.
ISSN:	1001-8417 1878-5964