When sustainability meets health and innovation: The case of Citrus by-products for cancer chemoprevention and applications in functional foods

Peel, pomace and seeds represent secondary products derived from production and manufacturing processes of Citrus spp. However, thanks to the novel policies of circular economy, sustainability and valorization of agro-wastes, Citrus by-products have become a precious source of energy and natural ben...

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Bibliographic Details
Published in:Biocatalysis and agricultural biotechnology 2024-06, Vol.58, p.103163, Article 103163
Main Authors: D'Amore, Teresa, Chaari, Moufida, Falco, Geppino, De Gregorio, Giuseppe, Zaraî Jaouadi, Nadia, Ali, Diyar Salahuddin, Sarkar, Tanmay, Smaoui, Slim
Format: Article
Language:English
Subjects:
Cancer
Chemoprevention
Citrus by-products
Delivery
Encapsulation
Extraction methods
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Summary:Peel, pomace and seeds represent secondary products derived from production and manufacturing processes of Citrus spp. However, thanks to the novel policies of circular economy, sustainability and valorization of agro-wastes, Citrus by-products have become a precious source of energy and natural beneficial compounds used for manifold applications, from biofuels to dietary supplements and nutraceuticals, to food additives and bio-preservatives. Several studies have been carried out to investigate the bioactivities, functionalize, stabilize and use these products or part of them (e.g., extracts, oils, powders, purified compounds). In this context, this study discusses properties, technological processing and extraction, functions and health implications of Citrus by-products as cancer chemopreventive agents, and lays a special emphasis on the stabilization, encapsulation and delivering of Citrus by-products phytochemicals and formulations. As the extraction and isolation are key aspects of phytochemicals availability the first objective of this study was to critically examine innovative and non-conventional techniques. Subsequently, to have a comprehensive understanding of bioactivity underlying the complex anticancer actions through various mechanisms, the methods/assays for antiproliferative, proapoptotic, anti-inflammatory, antioxidant activity evaluation were introduced, and the models and biomolecules were presented, using the methodologies of extensive literature search and meta-analysis. Upcoming perspectives and the current and future framework were also discussed.
ISSN:1878-8181
1878-8181
DOI:10.1016/j.bcab.2024.103163