Optimization of serologic diagnosis of celiac disease in the pediatric setting

The clinical presentation of celiac disease (CD) varies between children. The objective of this study was to document the pre-test probability for CD based on symptoms and routine laboratory test and to evaluate the performance of two IgA anti-tissue transglutaminase (tTG) assays. We critically revi...

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Bibliographic Details
Published in:	Autoimmunity reviews 2020-05, Vol.19 (5), p.102513, Article 102513
Main Authors:	Bogaert, Laura, Cauchie, Mathieu, Van Hoovels, Lieve, Vermeersch, Pieter, Fierz, Walter, De Hertogh, Gert, Hoffman, Ilse, Bossuyt, Xavier
Format:	Article
Language:	eng
Subjects:	Celiac disease IgA tissue transglutaminase Likelihood ratio Pre-test probability
Online Access:	Get full text
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Summary:	The clinical presentation of celiac disease (CD) varies between children. The objective of this study was to document the pre-test probability for CD based on symptoms and routine laboratory test and to evaluate the performance of two IgA anti-tissue transglutaminase (tTG) assays. We critically reviewed the concept of using multiples of the manufacturer's upper limit of normal (ULN), as proposed in the ESPGHAN guidelines (if IgA tTG is >10 times ULN, no biopsy is needed). The retrospective study included 91 children with newly diagnosed CD and 605 controls (
ISSN:	1568-9972 1568-9972