Are endometrial polyps true cancer precursors?

Objective The purpose of this study was to assess whether endometrial polyps (EMPs) represent cancer precursors. Study Design Age standardized incidence ratios (SIRs) of histologically verified endometrial cancers (EmCas) were estimated in women with EMPs and in women with uterine leiomyomata, which...

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Bibliographic Details
Published in:	American journal of obstetrics and gynecology 2010-09, Vol.203 (3), p.232.e1-232.e6
Main Authors:	Perri, Tamar, MD, Rahimi, Kurosh, MD, Ramanakumar, Agnihotram V., PhD, Wou, Karen, MD, Pilavdzic, Dragana, MD, Franco, Eduardo L., PhD, Gotlieb, Walter H., MD, PhD, Ferenczy, Alex, MD
Format:	Article
Language:	eng
Subjects:	Aged Biological and medical sciences cancer precursor Carcinoma - epidemiology Carcinoma - pathology Carcinosarcoma - epidemiology Carcinosarcoma - pathology endometrial cancer Endometrial Neoplasms - epidemiology Endometrial Neoplasms - pathology endometrial polyp Endometrium - pathology Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Hyperplasia Leiomyoma - epidemiology Leiomyoma - pathology leiomyomata Medical sciences Middle Aged Obstetrics and Gynecology Polyps - epidemiology Polyps - pathology Precancerous Conditions - epidemiology Precancerous Conditions - pathology Prevalence Retrospective Studies Tumors uterine bleeding Uterine Diseases - epidemiology Uterine Diseases - pathology Uterine Hemorrhage - etiology Uterine Neoplasms - epidemiology Uterine Neoplasms - pathology
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Summary:	Objective The purpose of this study was to assess whether endometrial polyps (EMPs) represent cancer precursors. Study Design Age standardized incidence ratios (SIRs) of histologically verified endometrial cancers (EmCas) were estimated in women with EMPs and in women with uterine leiomyomata, which is a condition that is unrelated to endometrial carcinogenesis. SIRs were calculated as the ratio of observed to expected EmCas based on age-specific incidence rates for female Montreal residents during the same period. Results Of 1467 women with EMPs, 125 (8.5%) had EmCa. Of 1138 patients with uterine leiomyomata, 133 (11.7%) had EmCa. The SIRs of EmCa for women with EMPs (odds ratio, 8.0; 95% confidence interval, 6.6–9.5) were significantly lower than that in women with leiomyomata (odds ratio, 19.1; 95% confidence interval, 16.0–22.6). Abnormal uterine bleeding was the main reason for evaluating patients with EMP with or without associated EmCa. Conclusion The findings of higher EmCa incidence are consistent with enhanced detection opportunity rather than with the endometrial cancer precursor potential of EMPs.
ISSN:	0002-9378 1097-6868