The Alzheimer-related gene presenilin-1 facilitates sonic hedgehog expression in Xenopus primary neurogenesis

We analyzed the influence of presenilins on the genetic cascades that control neuronal differentiation in Xenopus embryos. Resembling sonic hedgehog ( shh) overexpression, presenilin mRNA injection reduced the number of N-tubulin + primary neurons and modulated Gli3 and Zic2 according to their roles...

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Published in:	Mechanisms of development 2001-09, Vol.107 (1), p.119-131
Main Authors:	Paganelli, Alejandra R, Ocaña, Oscar H, Prat, Marı́a I, Franco, Paula G, López, Silvia L, Morelli, Laura, Adamo, Ana M, Riccomagno, Martı́n M, Matsubara, Etsuro, Shoji, Mikio, Affranchino, José L, Castaño, Eduardo M, Carrasco, Andrés E
Format:	Article
Language:	eng
Subjects:	Amyloid Precursor Protein Secretases Animals Apoptosis Aspartic Acid Endopeptidases Cell Differentiation Cell Division Central Nervous System - embryology DNA-Binding Proteins - genetics Down-Regulation Embryo, Nonmammalian - cytology Embryo, Nonmammalian - metabolism Endopeptidases - metabolism Gene Expression Regulation, Developmental Hedgehog Proteins In Situ Hybridization Kruppel-Like Transcription Factors Membrane Proteins - genetics Membrane Proteins - physiology Morpholino oligonucleotide Mutagenesis, Site-Directed Nerve Tissue Proteins Neurons - cytology Oligonucleotides, Antisense Presenilin Presenilin-1 Primary neurogenesis Proliferation Repressor Proteins Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Sonic hedgehog Trans-Activators - genetics Trans-Activators - physiology Transcription Factors - genetics Tretinoin - pharmacology Tubulin - genetics Tubulin - metabolism Xenopus laevis Xenopus laevis - embryology Xenopus laevis - genetics Xenopus laevis - metabolism Xenopus Proteins Zinc Finger Protein Gli3
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