Straightforward and general method for coupling alcohols to solid supports
A new method for attaching alcohols to solid supports has been developed employing dihydropyranfunctionalized resin. High loading levels are obtained for primary and secondary as well as functionalized alcohols. The attachment functionality is stable to both strongly basic and nucleophilic reagents....
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| Published in: | Tetrahedron letters 1994-12, Vol.35 (50), p.9333-9336 |
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| Main Authors: | , |
| Format: | Article |
| Language: | eng |
| Online Access: | Get full text |
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| Summary: | A new method for attaching alcohols to solid supports has been developed employing dihydropyranfunctionalized resin. High loading levels are obtained for primary and secondary as well as functionalized alcohols. The attachment functionality is stable to both strongly basic and nucleophilic reagents. However, the alcohols can readily be cleaved from the support with PPTS in 1:1 butanol/1,2-dichloroethane.
A new method is described for coupling alcohols to solid supports to provide an alcohol-derivatized resin that is stable to strongly basic or nucleophilic reagents. |
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| ISSN: | 0040-4039 1873-3581 |