The metabolism of ethylcyclohexane in Fischer 344 rats

The urinary metabolites of ethylcyclohexane (ECH) in male Fischer 344 rats, administered the hydrocarbon by gavage, included 4-ethylcyclohexanol, 2-hydroxy-4-ethylcyclohexanone, 2 c-hydroxy-4 c-ethylcyclohexanol, 2 c-hydroxy-4 t-ethylcyclohexanol, 2 t-hydroxy-4 c-ethylcyclohexanol and 2 t-hydroxy-4-...

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Bibliographic Details
Published in:Chemosphere (Oxford) 1990, Vol.20 (1), p.43-49
Main Authors: Serve', M.P., Roberts, J., McDonald, G.A., Parnell, M.J., Mattie, D.R., Hixson, C.J., Yu, K.O.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Medical sciences
Toxicology
Various organic compounds
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Summary:The urinary metabolites of ethylcyclohexane (ECH) in male Fischer 344 rats, administered the hydrocarbon by gavage, included 4-ethylcyclohexanol, 2-hydroxy-4-ethylcyclohexanone, 2 c-hydroxy-4 c-ethylcyclohexanol, 2 c-hydroxy-4 t-ethylcyclohexanol, 2 t-hydroxy-4 c-ethylcyclohexanol and 2 t-hydroxy-4- t-ethylcyclohexanol. The metabolites were identified using gasliquid partition chromatography (GC) and gas-liquid partition chromatography/mass spectrometry (GC/MS). Metabolism of ECH occurred exclusively on the ring. Histopathologic examination revealed mild to moderate renal damage.
ISSN:0045-6535
1879-1298
DOI:10.1016/0045-6535(90)90086-9