Embryos with a Mosaic Result: the Known and Unknown Reproductive Potential

Purpose of Review Interest regarding the transfer of embryos with a mosaic result has increased in recent years as outcome data continues to aggregate since the first published report of livebirths after the transfer of embryos with a mosaic result in 2015. The purpose of this review is to distill t...

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Bibliographic Details
Published in:Current obstetrics and gynecology reports 2021-12, Vol.10 (4), p.71-76
Main Authors: Romanski, Phillip A., Hariton, Eduardo
Format: Article
Language:English
Subjects:
Maternal and Child Health
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Oncology
Reproductive Endocrinology and Infertility (REI) (R Anchan
Section Editor
Topical Collection on Reproductive Endocrinology and Infertility (REI)
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Summary:Purpose of Review Interest regarding the transfer of embryos with a mosaic result has increased in recent years as outcome data continues to aggregate since the first published report of livebirths after the transfer of embryos with a mosaic result in 2015. The purpose of this review is to distill the available published literature on the transfer of embryos with a mosaic result in order to empower clinicians to understand and counsel patients on this topic. Recent Findings Embryos with a mosaic result have clear reproductive potential, though the live birth rate from these embryos is usually reported to be lower than euploid embryos. The transfer of these embryos is now common enough that researchers are developing ranking systems that prioritize different mosaic results based on their likelihood of yielding a live birth. The vast majority of published live births following the transfer of embryos with a mosaic result have been reported to be without phenotypic abnormality. However, many of these pregnancies have chosen to not perform prenatal diagnostic testing which limits our ability to understand the prevalence of mosaicism in newborns that result from the transfer of these embryos. To date, there has been at least one live birth of a newborn with mosaicism that resulted following the transfer of an embryo with a mosaic result. Summary While embryos with a mosaic result have the potential to result in a healthy live birth, the transfer of these embryos is not without risks, both known and unknown. Clinicians that utilize PGT-A with reporting of mosaic results must familiarize themselves with the current literature on outcomes following the transfer of mosaic embryos, and as more data emerges, recommendations and guidelines on this topic will likely continue to evolve. Patients that are considering the transfer of embryos with a mosaic result should understand the limitations of the current published outcome data and should receive extensive counseling both before and after the transfer of these embryos.
ISSN:2161-3303
2161-3303
DOI:10.1007/s13669-021-00317-0