Prognostic and Diagnostic Values of miR-506 and SPON 1 in Colorectal Cancer with Clinicopathological Considerations
Purpose One of the most common cancers in the world is colorectal cancer, which has increased significantly in recent decades. In the carcinogenicity process in the colon, there are genes involved in various cellular processes, such as cell cycle, apoptosis, and cell migration. According to studies...
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| Published in: | Journal of gastrointestinal cancer 2021-03, Vol.52 (1), p.125-129 |
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Prognostic and Diagnostic Values of miR-506 and SPON 1 in Colorectal Cancer with Clinicopathological Considerations |
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Article |
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Tamjidifar, Rozita Akbari, Morteza Tarzi, Saeed Sadeghzadeh, Mahsa Abolghasemi, Mahsa Poursaei, Elham Shomali, Navid Mahdavi, Farshad |
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Cancer Research Gastroenterology Internal Medicine Medicine Medicine & Public Health Oncology Original Research Radiotherapy |
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Journal of gastrointestinal cancer, 2021-03, Vol.52 (1), p.125-129 |
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Purpose
One of the most common cancers in the world is colorectal cancer, which has increased significantly in recent decades. In the carcinogenicity process in the colon, there are genes involved in various cellular processes, such as cell cycle, apoptosis, and cell migration. According to studies carried out, both miR-506 and SPON 1 genes are involved in the process which initiates and promotes cancer. In this study, alterations in the expression of target genes from the viewpoint of carcinogenicity were studied and evaluated.
Methods
Fifty tumor tissues and normal marginal tissue were collected from patients who were undergoing colorectal cancer surgery. After the extraction of RNA, the real-time PCR method was performed to evaluate the gene expression. Also, alterations of gene expression in response to defined amounts of chemotherapeutic drugs (IC50) were evaluated.
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ISSN: 1941-6628 |
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<record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1007_s12029_019_00356_0</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>31927744</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-866bf871faee31d47a47c6890ab404a6ae05882e400039662389def0a7f3df523</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EoqXwAyyQfyAwjh07WaLwlCpa8dpabmK3rlK7slMh_h63hS5ZjGZGc-9I9yB0SeCaAIibSHLIqwxIKqAFz-AIDUnFSMY55ceHOS8H6CzGJQBnBSGnaEBJlQvB2BDFafBz52NvG6xci--s-ls_VbfREXuDV_Y1K4DvBG_TyQsm2Dpc-84H3fSqw7VyjQ74y_YLXHfW2cavVb9Igrlttnfvom11UL1N0zk6MaqL-uK3j9DHw_17_ZSNJ4_P9e04aygTfVZyPjOlIEZpTUnLhGKi4WUFasaAKa40FGWZawYpfZVi0rJqtQElDG1NkdMRyvd_m-BjDNrIdbArFb4lAbklKPcEZSIodwQlJNPV3rTezFa6PVj-kCUB3QtiOrm5DnLpN8GlIP-9_QF63Hvl</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><isCDI>true</isCDI><recordtype>article</recordtype></control><display><type>article</type><title>Prognostic and Diagnostic Values of miR-506 and SPON 1 in Colorectal Cancer with Clinicopathological Considerations</title><source>Springer Nature - Connect here FIRST to enable access</source><source>Alma/SFX Local Collection</source><creator>Tamjidifar, Rozita ; Akbari, Morteza ; Tarzi, Saeed ; Sadeghzadeh, Mahsa ; Abolghasemi, Mahsa ; Poursaei, Elham ; Shomali, Navid ; Mahdavi, Farshad</creator><creatorcontrib>Tamjidifar, Rozita ; Akbari, Morteza ; Tarzi, Saeed ; Sadeghzadeh, Mahsa ; Abolghasemi, Mahsa ; Poursaei, Elham ; Shomali, Navid ; Mahdavi, Farshad</creatorcontrib><description>Purpose
One of the most common cancers in the world is colorectal cancer, which has increased significantly in recent decades. In the carcinogenicity process in the colon, there are genes involved in various cellular processes, such as cell cycle, apoptosis, and cell migration. According to studies carried out, both miR-506 and SPON 1 genes are involved in the process which initiates and promotes cancer. In this study, alterations in the expression of target genes from the viewpoint of carcinogenicity were studied and evaluated.
Methods
Fifty tumor tissues and normal marginal tissue were collected from patients who were undergoing colorectal cancer surgery. After the extraction of RNA, the real-time PCR method was performed to evaluate the gene expression. Also, alterations of gene expression in response to defined amounts of chemotherapeutic drugs (IC50) were evaluated.
P
< 0.05 was considered statistically significant.
Results
The relative expression level of miR-506 in tumor tissues was significantly decreased in comparison with healthy marginal tissues (
P
= 0.044). On the other hand, the SPON1 gene expression level was decreased too in tumor tissues in comparison with healthy marginal tissues (
P
= 0.019). There was also a significant relationship between the expression of target genes and clinicopathological involvement. However, there was no significant alteration in these genes along with the chemotherapeutic drug.
Conclusion
These findings suggest that the relative expression of miR-506 and SPON 1 gene can be considered as a diagnostic or predictive biomarker for colorectal cancer. However, further studies on protein levels should be conducted.</description><identifier>ISSN: 1941-6628</identifier><identifier>EISSN: 1941-6636</identifier><identifier>DOI: 10.1007/s12029-019-00356-0</identifier><identifier>PMID: 31927744</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Cancer Research ; Gastroenterology ; Internal Medicine ; Medicine ; Medicine & Public Health ; Oncology ; Original Research ; Radiotherapy</subject><ispartof>Journal of gastrointestinal cancer, 2021-03, Vol.52 (1), p.125-129</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-866bf871faee31d47a47c6890ab404a6ae05882e400039662389def0a7f3df523</citedby><cites>FETCH-LOGICAL-c347t-866bf871faee31d47a47c6890ab404a6ae05882e400039662389def0a7f3df523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12029-019-00356-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12029-019-00356-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,787,791,1655,27985,27986,41485,42554,51702</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31927744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tamjidifar, Rozita</creatorcontrib><creatorcontrib>Akbari, Morteza</creatorcontrib><creatorcontrib>Tarzi, Saeed</creatorcontrib><creatorcontrib>Sadeghzadeh, Mahsa</creatorcontrib><creatorcontrib>Abolghasemi, Mahsa</creatorcontrib><creatorcontrib>Poursaei, Elham</creatorcontrib><creatorcontrib>Shomali, Navid</creatorcontrib><creatorcontrib>Mahdavi, Farshad</creatorcontrib><title>Prognostic and Diagnostic Values of miR-506 and SPON 1 in Colorectal Cancer with Clinicopathological Considerations</title><title>Journal of gastrointestinal cancer</title><addtitle>J Gastrointest Canc</addtitle><addtitle>J Gastrointest Cancer</addtitle><description>Purpose
One of the most common cancers in the world is colorectal cancer, which has increased significantly in recent decades. In the carcinogenicity process in the colon, there are genes involved in various cellular processes, such as cell cycle, apoptosis, and cell migration. According to studies carried out, both miR-506 and SPON 1 genes are involved in the process which initiates and promotes cancer. In this study, alterations in the expression of target genes from the viewpoint of carcinogenicity were studied and evaluated.
Methods
Fifty tumor tissues and normal marginal tissue were collected from patients who were undergoing colorectal cancer surgery. After the extraction of RNA, the real-time PCR method was performed to evaluate the gene expression. Also, alterations of gene expression in response to defined amounts of chemotherapeutic drugs (IC50) were evaluated.
P
< 0.05 was considered statistically significant.
Results
The relative expression level of miR-506 in tumor tissues was significantly decreased in comparison with healthy marginal tissues (
P
= 0.044). On the other hand, the SPON1 gene expression level was decreased too in tumor tissues in comparison with healthy marginal tissues (
P
= 0.019). There was also a significant relationship between the expression of target genes and clinicopathological involvement. However, there was no significant alteration in these genes along with the chemotherapeutic drug.
Conclusion
These findings suggest that the relative expression of miR-506 and SPON 1 gene can be considered as a diagnostic or predictive biomarker for colorectal cancer. However, further studies on protein levels should be conducted.</description><subject>Cancer Research</subject><subject>Gastroenterology</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Research</subject><subject>Radiotherapy</subject><issn>1941-6628</issn><issn>1941-6636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRS0EoqXwAyyQfyAwjh07WaLwlCpa8dpabmK3rlK7slMh_h63hS5ZjGZGc-9I9yB0SeCaAIibSHLIqwxIKqAFz-AIDUnFSMY55ceHOS8H6CzGJQBnBSGnaEBJlQvB2BDFafBz52NvG6xci--s-ls_VbfREXuDV_Y1K4DvBG_TyQsm2Dpc-84H3fSqw7VyjQ74y_YLXHfW2cavVb9Igrlttnfvom11UL1N0zk6MaqL-uK3j9DHw_17_ZSNJ4_P9e04aygTfVZyPjOlIEZpTUnLhGKi4WUFasaAKa40FGWZawYpfZVi0rJqtQElDG1NkdMRyvd_m-BjDNrIdbArFb4lAbklKPcEZSIodwQlJNPV3rTezFa6PVj-kCUB3QtiOrm5DnLpN8GlIP-9_QF63Hvl</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Tamjidifar, Rozita</creator><creator>Akbari, Morteza</creator><creator>Tarzi, Saeed</creator><creator>Sadeghzadeh, Mahsa</creator><creator>Abolghasemi, Mahsa</creator><creator>Poursaei, Elham</creator><creator>Shomali, Navid</creator><creator>Mahdavi, Farshad</creator><general>Springer US</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20210301</creationdate><title>Prognostic and Diagnostic Values of miR-506 and SPON 1 in Colorectal Cancer with Clinicopathological Considerations</title><author>Tamjidifar, Rozita ; Akbari, Morteza ; Tarzi, Saeed ; Sadeghzadeh, Mahsa ; Abolghasemi, Mahsa ; Poursaei, Elham ; Shomali, Navid ; Mahdavi, Farshad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-866bf871faee31d47a47c6890ab404a6ae05882e400039662389def0a7f3df523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cancer Research</topic><topic>Gastroenterology</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Research</topic><topic>Radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tamjidifar, Rozita</creatorcontrib><creatorcontrib>Akbari, Morteza</creatorcontrib><creatorcontrib>Tarzi, Saeed</creatorcontrib><creatorcontrib>Sadeghzadeh, Mahsa</creatorcontrib><creatorcontrib>Abolghasemi, Mahsa</creatorcontrib><creatorcontrib>Poursaei, Elham</creatorcontrib><creatorcontrib>Shomali, Navid</creatorcontrib><creatorcontrib>Mahdavi, Farshad</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of gastrointestinal cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tamjidifar, Rozita</au><au>Akbari, Morteza</au><au>Tarzi, Saeed</au><au>Sadeghzadeh, Mahsa</au><au>Abolghasemi, Mahsa</au><au>Poursaei, Elham</au><au>Shomali, Navid</au><au>Mahdavi, Farshad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic and Diagnostic Values of miR-506 and SPON 1 in Colorectal Cancer with Clinicopathological Considerations</atitle><jtitle>Journal of gastrointestinal cancer</jtitle><stitle>J Gastrointest Canc</stitle><addtitle>J Gastrointest Cancer</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>52</volume><issue>1</issue><spage>125</spage><epage>129</epage><pages>125-129</pages><issn>1941-6628</issn><eissn>1941-6636</eissn><abstract>Purpose
One of the most common cancers in the world is colorectal cancer, which has increased significantly in recent decades. In the carcinogenicity process in the colon, there are genes involved in various cellular processes, such as cell cycle, apoptosis, and cell migration. According to studies carried out, both miR-506 and SPON 1 genes are involved in the process which initiates and promotes cancer. In this study, alterations in the expression of target genes from the viewpoint of carcinogenicity were studied and evaluated.
Methods
Fifty tumor tissues and normal marginal tissue were collected from patients who were undergoing colorectal cancer surgery. After the extraction of RNA, the real-time PCR method was performed to evaluate the gene expression. Also, alterations of gene expression in response to defined amounts of chemotherapeutic drugs (IC50) were evaluated.
P
< 0.05 was considered statistically significant.
Results
The relative expression level of miR-506 in tumor tissues was significantly decreased in comparison with healthy marginal tissues (
P
= 0.044). On the other hand, the SPON1 gene expression level was decreased too in tumor tissues in comparison with healthy marginal tissues (
P
= 0.019). There was also a significant relationship between the expression of target genes and clinicopathological involvement. However, there was no significant alteration in these genes along with the chemotherapeutic drug.
Conclusion
These findings suggest that the relative expression of miR-506 and SPON 1 gene can be considered as a diagnostic or predictive biomarker for colorectal cancer. However, further studies on protein levels should be conducted.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31927744</pmid><doi>10.1007/s12029-019-00356-0</doi></addata></record> |