Prognostic and Diagnostic Values of miR-506 and SPON 1 in Colorectal Cancer with Clinicopathological Considerations

Purpose One of the most common cancers in the world is colorectal cancer, which has increased significantly in recent decades. In the carcinogenicity process in the colon, there are genes involved in various cellular processes, such as cell cycle, apoptosis, and cell migration. According to studies...

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Bibliographic Details
Published in:	Journal of gastrointestinal cancer 2021-03, Vol.52 (1), p.125-129
Main Authors:	Tamjidifar, Rozita, Akbari, Morteza, Tarzi, Saeed, Sadeghzadeh, Mahsa, Abolghasemi, Mahsa, Poursaei, Elham, Shomali, Navid, Mahdavi, Farshad
Format:	Article
Language:	eng
Subjects:	Cancer Research Gastroenterology Internal Medicine Medicine Medicine & Public Health Oncology Original Research Radiotherapy
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Summary:	Purpose One of the most common cancers in the world is colorectal cancer, which has increased significantly in recent decades. In the carcinogenicity process in the colon, there are genes involved in various cellular processes, such as cell cycle, apoptosis, and cell migration. According to studies carried out, both miR-506 and SPON 1 genes are involved in the process which initiates and promotes cancer. In this study, alterations in the expression of target genes from the viewpoint of carcinogenicity were studied and evaluated. Methods Fifty tumor tissues and normal marginal tissue were collected from patients who were undergoing colorectal cancer surgery. After the extraction of RNA, the real-time PCR method was performed to evaluate the gene expression. Also, alterations of gene expression in response to defined amounts of chemotherapeutic drugs (IC50) were evaluated. P
ISSN:	1941-6628 1941-6636