Comparison of automated protocol-based versus non-protocol-based physician-directed weaning from mechanical ventilation: A controlled clinical trial
Rationale and objectives In the weaning of patients from mechanical ventilation by gradually reducing pressure support ventilation (PSV), an automated computerized system recently proved to be superior to traditional physician-directed weaning. The aim of this study was to replicate these findings w...
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| Published in: | Intensivmedizin + Notfallmedizin 2009, Vol.46 (6), p.441-446 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | eng |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Rationale and objectives
In the weaning of patients from mechanical ventilation by gradually reducing pressure support ventilation (PSV), an automated computerized system recently proved to be superior to traditional physician-directed weaning. The aim of this study was to replicate these findings when weaning a broad surgical intensive care unit (ICU) patient population off the ventilator.
Methods and measurements
Sixty patients requiring mechanical ventilation over 24 h were randomized to either automated (n = 30) or physician-directed (n = 30) weaning. The primary endpoint was duration of weaning. Secondary endpoints were duration of mechanical ventilation, length of ICU stay, reintubation rates, and workload for staff.
Results
Weaning duration did not differ significantly between the computer-driven group and the physician-directed group (0.64 vs. 2.33 d, 95%CI: -0.10 to 2.15, p = 0.167). No significant differences were detected for any secondary endpoint except the workload for PSV settings, which was lower in the computer-driven weaning group (0.0 vs. 0.15 settings/h, p |
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| ISSN: | 0175-3851 1435-1420 |