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No association of obesity gene FTO with body composition at the age of 6 months. The Generation R Study
Background : Genome-wide association studies on body mass index (BMI) have identified an FTO polymorphism (rs9939609) as having the strongest effect. Aim : We examined the effect of FTO genotype on body composition at the age of 6 months using skinfold thickness measurements and dual energy X-ray ab...
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Published in: | Journal of endocrinological investigation 2011, Vol.34 (1), p.16-20 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Background
: Genome-wide association studies on body mass index (BMI) have identified an
FTO
polymorphism (rs9939609) as having the strongest effect.
Aim
: We examined the effect of
FTO
genotype on body composition at the age of 6 months using skinfold thickness measurements and dual energy X-ray absorptiometry (DXA).
Material/subjects and methods
: This study was embedded in a population-based prospective cohort study from early fetal life onwards.
FTO
genotype was related to anthropometric measurements (weight and height), subcutaneous fat mass measured by skinfold thickness, and total, truncal, and peripheral fat mass and lean mass measured by DXA. Analyses for skinfold thickness and DXA were performed in 695 and 216 children, respectively.
Results
: Genotype frequency was TT 40.3%, TA 45.5%, and AA 14.2%. No significant differences between
FTO
genotypes were found in weight, height or BMI. Furthermore,
FTO
genotype was not associated with any skinfold thickness. Finally, no associations between
FTO
genotype and body composition measures (fat and lean mass) assessed by DXA were found.
Conclusions: We
observed no association between this
FTO
polymorphism and body composition at the age of 6 months. Longer follow-up studies are necessary to examine at which age and by which mechanisms
FTO
genotype starts to influence fat mass and body composition. |
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ISSN: | 0391-4097 1720-8386 |
DOI: | 10.1007/BF03346689 |