Epidermal growth factor increases tissue antioxidant enzyme activities in ethanol-induced gastric injury in rat

The aim of the present study is to investigate whether the antioxidant mechanisms are involved in epidermal growth factor (EGF)-mediated protection from ethanol-induced gastric damage. Twenty four female Sprague-Dawley rats were assigned into 3 groups; control (C) group (n=8) was given physiologic s...

Full description

Saved in:
Bibliographic Details
Published in:Journal of physiology and biochemistry 2006-12, Vol.62 (4), p.237-243
Main Authors: Koken, T, Erkasap, N, Serteser, M, Kahraman, A
Format: Article
Language:English
Subjects:
Animals
Antioxidants - metabolism
Catalase - metabolism
Epidermal Growth Factor - pharmacology
Ethanol - toxicity
Female
Peroxidase - metabolism
Rats
Rats, Sprague-Dawley
Stomach - drug effects
Stomach - enzymology
Superoxide Dismutase - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of the present study is to investigate whether the antioxidant mechanisms are involved in epidermal growth factor (EGF)-mediated protection from ethanol-induced gastric damage. Twenty four female Sprague-Dawley rats were assigned into 3 groups; control (C) group (n=8) was given physiologic saline by gavage; ethanol (E) group (n=8) was given 1 ml of 80% ethanol (v/v) in distilled water by gavage and EGF group (n=8) was given EGF (100 mg/kg-body wt.) intraperitonealy half an hour before the administration of ethanol. The protein carbonyl content was significantly higher in the E group than the C group (p
ISSN:1138-7548
1877-8755
DOI:10.1007/BF03165752