Role of preoperative administration of bleomycin and radiation in the treatment of esophageal cancer

The preoperative use of Bleomycin (BLM) alone or combined with irradiation in the treatment of esophageal cancer was evaluated in 58 patients who underwent surgical removal of the lesion for the past three and a half years. Histologic study showed such preoperative treatment is effective in inducing...

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Bibliographic Details
Published in:Japanese journal of surgery 1975-03, Vol.5 (1), p.48-55
Main Authors: Fujimake, M, Soga, J, Kawaguchi, M, Maeda, M, Sasaki, K
Format: Article
Language:English
Subjects:
Adult
Aged
Bleomycin - adverse effects
Bleomycin - therapeutic use
Cobalt Radioisotopes - therapeutic use
Esophageal Neoplasms - drug therapy
Esophageal Neoplasms - radiotherapy
Esophageal Neoplasms - therapy
Female
Humans
Lymphatic Metastasis
Male
Middle Aged
Preoperative Care
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Summary:The preoperative use of Bleomycin (BLM) alone or combined with irradiation in the treatment of esophageal cancer was evaluated in 58 patients who underwent surgical removal of the lesion for the past three and a half years. Histologic study showed such preoperative treatment is effective in inducing favorable changes in neoplastic cells in 69 per cent (40/58) of the primary lesions and in a significant number of involved lymph nodes of the second or the third groups. The study clearly suggests that preoperative Bleomycin administration combined with irradiation may be an useful adjunct preoperative procedure in esophageal cancer.
ISSN:0047-1909
1436-2813
DOI:10.1007/bf02469469