Gastroduodenal manifestations in patients with skeletal fluorosis

A prospective case-controlled study was performed to evaluate the gastrointestinal symptoms and mucosal abnormalities occurring in patients with osteofluorosis. Ten patients with documented osteofluorosis and ten age- and sex-matched healthy volunteers were included in the study. Clinical evaluation...

Full description

Saved in:
Bibliographic Details
Published in:Journal of gastroenterology 1996-06, Vol.31 (3), p.333-337
Main Authors: Dasarathy, S, Das, T K, Gupta, I P, Susheela, A K, Tandon, R K
Format: Article
Language:English
Subjects:
Abdominal Pain - chemically induced
Adult
Bone Diseases - chemically induced
Bone Diseases - epidemiology
Case-Control Studies
Duodenitis - chemically induced
Duodenitis - diagnosis
Female
Fluoride Poisoning - complications
Fluoride Poisoning - epidemiology
Gastric Mucosa - ultrastructure
Gastritis, Atrophic - chemically induced
Gastritis, Atrophic - diagnosis
Humans
India - epidemiology
Intestinal Mucosa - ultrastructure
Male
Microscopy, Electron, Scanning
Microvilli - ultrastructure
Prospective Studies
Water Supply
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A prospective case-controlled study was performed to evaluate the gastrointestinal symptoms and mucosal abnormalities occurring in patients with osteofluorosis. Ten patients with documented osteofluorosis and ten age- and sex-matched healthy volunteers were included in the study. Clinical evaluation, real-time ultrasound, and upper gastrointestinal endoscopy and biopsy from the gastric antrum and duodenum were performed in all subjects. The biopsies were subjected to a rapid urease test and light and electron microscopic examinations. Ionic fluoride levels were estimated in the drinking water, serum, and urine using an ION 85 ion analyzer. All patients with osteofluorosis had gastrointestinal symptoms, the most common being abdominal pain. Endoscopic abnormalities were found in seven patients with osteofluorosis. In all 7 of these patients, chronic atrophic gastritis was seen on histology. Electron microscopic abnormalities were observed in all 10 patients with osteofluorosis. These included loss of microvilli, cracked-clay appearance, and the presence of surface abrasions on the mucosal cells. None of the control subjects had any clinical symptoms or mucosal abnormalities. It was concluded that gastrointestinal symptoms as well as mucosal abnormalities are common in patients with osteofluorosis.
ISSN:0944-1174
1435-5922
DOI:10.1007/BF02355021