Sedation in the ICU

The effect of midazolam on the induction dose-response curve for alfentanil was studied in non-premedicated ASA physical status I or II patients. The response to the verbal command was used as an end point of anaesthesia. Dose-response curves for midazolam, alfentanil, and their combination were det...

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Bibliographic Details
Published in:Intensive care medicine 1991, Vol.17 (S1), p.S20-S23
Main Authors: VINIK, H. R, KISSIN, I
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alfentanil - administration & dosage
Biological and medical sciences
Critical Care
Dose-Response Relationship, Drug
Double-Blind Method
Drug Combinations
Drug Synergism
Female
Humans
Hypnotics. Sedatives
Intensive Care Units
Medical sciences
Midazolam - administration & dosage
Middle Aged
Neuropharmacology
Pharmacology. Drug treatments
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
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Summary:The effect of midazolam on the induction dose-response curve for alfentanil was studied in non-premedicated ASA physical status I or II patients. The response to the verbal command was used as an end point of anaesthesia. Dose-response curves for midazolam, alfentanil, and their combination were determined with a probit procedure, and compared with algebraic (fractional) analysis of drug interaction. Interaction between midazolam and alfentanil was found to be synergistic (supra-additive). The results suggest that the use of this combination is advantageous not only because it helps to achieve different anaesthetic goals with specific drugs (a benzodiazepine for unconsciousness and an opioid for blockade of the responses to noxious stimulation), but also because its components are complementary for unconsciousness.
ISSN:0342-4642
1432-1238
DOI:10.1007/BF01731150