A CASE OF HISTIOCYTIC NECROTIZING LYMPHADENITIS WITH BONE-MARROW AND SKIN INVOLVEMENT

We report a case of histiocytic necrotizing lymphadenitis (HNL) with bone marrow extension in a 29-year-old male in which many large mononuclear cells infiltrated the bone marrow and mimicked malignant lymphoma. A lymph node biopsy confirmed the diagnosis of HNL. Immunohistologically, the infiltrati...

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Bibliographic Details
Published in:Virchows Archiv A Pathological Anatomy and Histopathology 1992-05, Vol.420 (3), p.275-279
Main Authors: SUMIYOSHI, Y, KIKUCHI, M, OHSHIMA, K, MASUDA, Y, TAKESHITA, M, OKAMURA, T
Format: Article
Language:English
Subjects:
Adult
Anatomy & Morphology
Biological and medical sciences
Biomarkers
Biopsy
Bone Marrow - pathology
Hematologic and hematopoietic diseases
Humans
Immunohistochemistry
Life Sciences & Biomedicine
Lymph Nodes - pathology
Lymphadenitis - pathology
Male
Medical sciences
Muramidase - analysis
Pathology
Science & Technology
Skin - pathology
T-Lymphocytes - immunology
T-Lymphocytes - pathology
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Summary:We report a case of histiocytic necrotizing lymphadenitis (HNL) with bone marrow extension in a 29-year-old male in which many large mononuclear cells infiltrated the bone marrow and mimicked malignant lymphoma. A lymph node biopsy confirmed the diagnosis of HNL. Immunohistologically, the infiltrating cells in the bone marrow were positive for lysozyme, LeuM1, Kp-1 and T-cell markers. The cells did not show haemophagocytosis. A skin biopsy from an accompanying facial skin rash revealed a proliferation of large cells similar to those observed in affected foci of the lymph node in subcutaneous tissue. The infiltrating cells were mainly lysozyme and Kp-1-positive histiocytes, some with phagocytosis of nuclear debris but none characteristic of haemophagocytosis. Transformed T-cells were also infiltrating.
ISSN:0174-7398
1432-2307
DOI:10.1007/BF01600281