Recombinant human growth hormone treatment of children with chronic renal failure : long-term (1- to 3-year) outcome

Treatment of nine boys, aged 2.8-16.3 years, with growth retardation consequent to chronic renal failure (CRF), with recombinant human growth hormone (rhGH) for 12-36 months demonstrated a significant improvement in growth velocity at each 12-month interval compared with that achieved the year prior...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 1991-07, Vol.5 (4), p.477-481
Main Authors: FINE, R. N, PYKE-GRIMM, K, NELSON, P. A, BOECHAT, M. I, LIPPE, B. M, YADIN, O, KAMIL, E
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Blood Glucose
Child
Child, Preschool
Creatinine - blood
Creatinine - urine
Growth
Growth Disorders - drug therapy
Growth Disorders - etiology
Growth Hormone - therapeutic use
Hormones. Endocrine system
Humans
Insulin - blood
Insulin-Like Growth Factor I - analysis
Kidney - physiopathology
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - physiopathology
Longitudinal Studies
Male
Medical sciences
Pharmacology. Drug treatments
Prognosis
Recombinant Proteins - therapeutic use
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Summary:Treatment of nine boys, aged 2.8-16.3 years, with growth retardation consequent to chronic renal failure (CRF), with recombinant human growth hormone (rhGH) for 12-36 months demonstrated a significant improvement in growth velocity at each 12-month interval compared with that achieved the year prior to treatment. Despite the acceleration in growth velocity the bone age did not increase more than the increase in chronological age during the period of treatment. The mean calculated creatinine clearance did not decrease significantly during the 36 months of treatment; however, two patients required institution of dialysis at 18 and 30 months following the initiation of rhGH treatment. There was no exacerbation of the glucose intolerance of uremia following rhGH treatment. Currently, six of seven patients who have been treated for more than 24 months have achieved sufficient acceleration of growth velocity to attain a standard deviation score that was more positive than -2.00, and are above the 5th per centile for chronological age on the growth curve. These data indicate that rhGH treatment of growth-retarded children with CRF results in accelerated growth velocity during the 2nd and 3rd years of treatment, and demonstrate the potential for such children to achieve normal stature for chronological age despite the continued presence of renal failure.
ISSN:0931-041X
1432-198X
DOI:10.1007/BF01453685