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Selectivity of small intestinal exudate in celiac disease and Crohn's disease
The small intestinal exudates of patients with protein-losing enteropathies produced by celiac disease or proximal jejunal Crohn's disease were compared with controls. The exudates in control subjects were highly selective, whereas those of the celiac and Crohn's disease subjects were rela...
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Published in: | American journal of digestive diseases 1978-01, Vol.23 (1), p.33-38 |
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container_title | American journal of digestive diseases |
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creator | Kingham, J G Loehry, C A |
description | The small intestinal exudates of patients with protein-losing enteropathies produced by celiac disease or proximal jejunal Crohn's disease were compared with controls. The exudates in control subjects were highly selective, whereas those of the celiac and Crohn's disease subjects were relatively nonselective. It is believed that this loss of selectivity is secondary to basement membrane damage. An analogy is drawn with the renal lesion in nephrotic syndrome where basement membrane damage is associated with nonselective proteinuria. |
doi_str_mv | 10.1007/BF01072572 |
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An analogy is drawn with the renal lesion in nephrotic syndrome where basement membrane damage is associated with nonselective proteinuria.</description><subject>Adult</subject><subject>Basement Membrane - pathology</subject><subject>Celiac Disease - pathology</subject><subject>Celiac Disease - physiopathology</subject><subject>Cell Membrane Permeability</subject><subject>Crohn Disease - pathology</subject><subject>Crohn Disease - physiopathology</subject><subject>Exudates and Transudates - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Intestinal Absorption</subject><subject>Intestinal Mucosa - physiopathology</subject><subject>Intestine, Small - pathology</subject><subject>Intestine, Small - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Povidone - metabolism</subject><issn>0002-9211</issn><issn>2168-779X</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><recordid>eNpFkEtLw0AUhQfxVasb1y5mpSBE55F5ZKnFqlBxoYK7MI87OJJHzSRi_72RVl1dOPfjcPgQOqbkghKiLq_nhBLFhGJbaMKo1JlSxes2mhBCWFYwSvfRQUrvhHCmtNhDu5IWkvEJeniCClwfP2O_wm3AqTZVhWPTQ-pjYyoMX4M3PYwRdlBF47CPCUwCbBqPZ1371pyl3-wQ7QRTJTja3Cl6md88z-6yxePt_exqkTmmaZ_lNoDNuQdOpBJMg9XUeg4i2FCAFTwI44SzWueeujx3Uhrp3PigSoK3fIpO173Lrv0YxqllHdM4rzINtEMqNddUKKpH8HwNuq5NqYNQLrtYm25VUlL-qCv_1Y3wyaZ1sDX4P3Ttin8DL7hpkA</recordid><startdate>197801</startdate><enddate>197801</enddate><creator>Kingham, J G</creator><creator>Loehry, C A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197801</creationdate><title>Selectivity of small intestinal exudate in celiac disease and Crohn's disease</title><author>Kingham, J G ; Loehry, C A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-4bfeb43de3067528eb81bd3e5fbf9eb53f5ac5cb884d1c44c66a6ccb53176edb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Adult</topic><topic>Basement Membrane - pathology</topic><topic>Celiac Disease - pathology</topic><topic>Celiac Disease - physiopathology</topic><topic>Cell Membrane Permeability</topic><topic>Crohn Disease - pathology</topic><topic>Crohn Disease - physiopathology</topic><topic>Exudates and Transudates - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Intestinal Absorption</topic><topic>Intestinal Mucosa - physiopathology</topic><topic>Intestine, Small - pathology</topic><topic>Intestine, Small - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Povidone - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kingham, J G</creatorcontrib><creatorcontrib>Loehry, C A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of digestive diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kingham, J G</au><au>Loehry, C A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selectivity of small intestinal exudate in celiac disease and Crohn's disease</atitle><jtitle>American journal of digestive diseases</jtitle><addtitle>Am J Dig Dis</addtitle><date>1978-01</date><risdate>1978</risdate><volume>23</volume><issue>1</issue><spage>33</spage><epage>38</epage><pages>33-38</pages><issn>0002-9211</issn><eissn>2168-779X</eissn><eissn>1573-2568</eissn><notes>ObjectType-Case Study-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-4</notes><notes>content type line 23</notes><notes>ObjectType-Report-1</notes><notes>ObjectType-Article-3</notes><abstract>The small intestinal exudates of patients with protein-losing enteropathies produced by celiac disease or proximal jejunal Crohn's disease were compared with controls. The exudates in control subjects were highly selective, whereas those of the celiac and Crohn's disease subjects were relatively nonselective. It is believed that this loss of selectivity is secondary to basement membrane damage. An analogy is drawn with the renal lesion in nephrotic syndrome where basement membrane damage is associated with nonselective proteinuria.</abstract><cop>United States</cop><pmid>619623</pmid><doi>10.1007/BF01072572</doi><tpages>6</tpages></addata></record> |
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source | Springer Online Journal Archives |
subjects | Adult Basement Membrane - pathology Celiac Disease - pathology Celiac Disease - physiopathology Cell Membrane Permeability Crohn Disease - pathology Crohn Disease - physiopathology Exudates and Transudates - physiology Female Humans Intestinal Absorption Intestinal Mucosa - physiopathology Intestine, Small - pathology Intestine, Small - physiopathology Male Middle Aged Povidone - metabolism |
title | Selectivity of small intestinal exudate in celiac disease and Crohn's disease |
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