Selectivity of small intestinal exudate in celiac disease and Crohn's disease

The small intestinal exudates of patients with protein-losing enteropathies produced by celiac disease or proximal jejunal Crohn's disease were compared with controls. The exudates in control subjects were highly selective, whereas those of the celiac and Crohn's disease subjects were rela...

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Bibliographic Details
Published in:American journal of digestive diseases 1978-01, Vol.23 (1), p.33-38
Main Authors: Kingham, J G, Loehry, C A
Format: Article
Language:English
Subjects:
Adult
Basement Membrane - pathology
Celiac Disease - pathology
Celiac Disease - physiopathology
Cell Membrane Permeability
Crohn Disease - pathology
Crohn Disease - physiopathology
Exudates and Transudates - physiology
Female
Humans
Intestinal Absorption
Intestinal Mucosa - physiopathology
Intestine, Small - pathology
Intestine, Small - physiopathology
Male
Middle Aged
Povidone - metabolism
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Summary:The small intestinal exudates of patients with protein-losing enteropathies produced by celiac disease or proximal jejunal Crohn's disease were compared with controls. The exudates in control subjects were highly selective, whereas those of the celiac and Crohn's disease subjects were relatively nonselective. It is believed that this loss of selectivity is secondary to basement membrane damage. An analogy is drawn with the renal lesion in nephrotic syndrome where basement membrane damage is associated with nonselective proteinuria.
ISSN:0002-9211
2168-779X
1573-2568
DOI:10.1007/BF01072572