The interaction of the calcium channel blockers verapamil and nifedipine with cyclosporin A in pediatric renal transplant patients

The elimination of cyclosporin A was assessed in eight pediatric renal transplant patients who received calcium channel blockers concomitantly with their immunosuppressive therapy. In three children, verapamil decreased the rate of elimination of cyclosporin A. In five children who received nifedipi...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 1994-08, Vol.8 (4), p.408-411
Main Authors: CROCKER, J. F. S, RENTON, K. W, LEVATTE, T. L, MCLELLAN, D. H
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Child
Child, Preschool
Cyclosporine - pharmacokinetics
Cyclosporine - therapeutic use
Drug Interactions
Graft Rejection - drug therapy
Half-Life
Humans
Hypertension - drug therapy
Kidney Transplantation
Medical sciences
Nifedipine - pharmacology
Nifedipine - therapeutic use
Pharmacology. Drug treatments
Urinary system
Verapamil - pharmacology
Verapamil - therapeutic use
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Summary:The elimination of cyclosporin A was assessed in eight pediatric renal transplant patients who received calcium channel blockers concomitantly with their immunosuppressive therapy. In three children, verapamil decreased the rate of elimination of cyclosporin A. In five children who received nifedipine, cyclosporin A elimination was also impaired, which contrasts with the reports in adult patients indicating that this calcium channel blocker has no effect on cyclosporin A elimination. When both calcium channel blockers were used on separate occasions in the same patient, nifedipine was less potent than verapamil in depressing cyclosporin A elimination. Although the number of subjects studied is small, these results likely indicate that nifedipine, as well as other calcium channel blocking drugs, must be used with caution in pediatric renal transplant patients.
ISSN:0931-041X
1432-198X
DOI:10.1007/BF00856514