Increased uptake on indium-111 pentetreotide up to 10 years after external thoracic irradiation : report of two cases

Indium-111 pentetreotide scintigraphy was performed in two patients for the localization of recurrent medullary thyroid carcinoma treated by surgery and external radiotherapy 1 and 10 years earlier. A marked uptake of the radiopharmaceutical was demonstrated in the lung areas that had been irradiate...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 1996-06, Vol.23 (6), p.723-726
Main Authors: STOFFEL, M, JAMAR, F, DONCKIER, J, HAINAUT, P, DECOSTER, P, BECKERS, C, PAUWELS, S
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Carcinoma, Medullary - diagnostic imaging
Carcinoma, Medullary - radiotherapy
Diagnosis, Differential
Endocrine glands. Genital system. Mammary gland
False Positive Reactions
Humans
Indium Radioisotopes
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Neoplasm Recurrence, Local - diagnostic imaging
Radiation Pneumonitis - diagnostic imaging
Radionuclide Imaging
Radionuclide investigations
Somatostatin - analogs & derivatives
Thyroid Neoplasms - diagnostic imaging
Thyroid Neoplasms - radiotherapy
Time Factors
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Summary:Indium-111 pentetreotide scintigraphy was performed in two patients for the localization of recurrent medullary thyroid carcinoma treated by surgery and external radiotherapy 1 and 10 years earlier. A marked uptake of the radiopharmaceutical was demonstrated in the lung areas that had been irradiated. These cases strongly suggest that this uptake is related to pulmonary fibrosis, a well-known complication of radiotherapy, even long after the irradiation. Therefore, attention must be paid to the avoidance of false-positive interpretation of somatostatin receptor scintigraphy in patients previously treated by radiotherapy.
ISSN:0340-6997
1619-7089
DOI:10.1007/BF00834537