Investigations of the estrogen (ER-ICA-test) and the progesterone receptor in the prostate and prostatic carcinoma of immunohistochemical basis

Estrogen (ER) and Progesterone receptors (PR) were demonstrated immunohistochemically on frozen sections from 11 prostatectomy and 7 cystoprostatectomy specimens in the nuclei of various cell types. The periglandular fibrocytes and smooth muscle cells were extensively positive, the interglandular st...

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Bibliographic Details
Published in:Virchows Archiv A Pathological Anatomy and Histopathology 1988-01, Vol.412 (4), p.387-391
Main Authors: WERNERT, N, GERDES, J, LOY, V, SEITZ, G, SCHERR, O, DHOM, G
Format: Article
Language:English
Subjects:
Biological and medical sciences
Humans
Immunohistochemistry - methods
Male
Medical sciences
Nephrology. Urinary tract diseases
Prostate - ultrastructure
Prostatic Neoplasms - ultrastructure
Reagent Kits, Diagnostic
Receptors, Estrogen - analysis
Receptors, Progesterone - analysis
Tumors of the urinary system
Urinary tract. Prostate gland
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Summary:Estrogen (ER) and Progesterone receptors (PR) were demonstrated immunohistochemically on frozen sections from 11 prostatectomy and 7 cystoprostatectomy specimens in the nuclei of various cell types. The periglandular fibrocytes and smooth muscle cells were extensively positive, the interglandular stromal cells were only partly so. Normal basal cells stained focally positive, hyperplastic basal cells stained extensively. The glandular secretory epithelium and atrophic glands were negative. The same findings were obtained in hyperplastic nodules. Both ER and PR also occurred in the urothelium of central prostatic ducts and of the prostatic urethra. The fibrous stroma around the ejaculatory ducts and seminal vesicles was extensively positive while the epithelium was negative. The smooth musculature of the seminal vesicles was only partly positive. On large field sections, the ER as well as the PR were numerically equally distributed throughout the inner zone of the prostate and the prostate proper. 12 prostatic carcinomas (G I-G III) were ER- and PR-negative. Estrogens may contribute to nodular hyperplasia by triggering a stromal proliferation with a secondary inductive epithelial growth. Obviously they do not act directly on prostatic carcinoma but inhibit growth via the hypophyseal-testicular axis. The biological significance of the PR in the prostate is unknown.
ISSN:0174-7398
1432-2307
DOI:10.1007/BF00750267