Coexistence of renin and cathepsin B in epithelioid cell secretory granules

Mature juxtaglomerular epithelioid cell secretory granules of the rat exhibit both renin- and cathepsin B-like immunoreactivity. On the basis of the coexistence with renin at a pH which, according to previous experiments, is probably in the range of that in lysosomes, cathepsin B is suggested to be...

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Bibliographic Details
Published in:Histochemistry 1985-01, Vol.83 (2), p.103-108
Main Authors: TAUGNER, R, BUHRLE, C. P, NOBILING, R, KIRSCHKE, H
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cathepsin B
Cathepsins - metabolism
Cytoplasmic Granules - metabolism
Endocrine kidney. Renin-angiotensin-aldosterone system
Epithelium - enzymology
Epithelium - ultrastructure
Fundamental and applied biological sciences. Psychology
Juxtaglomerular Apparatus - enzymology
Juxtaglomerular Apparatus - ultrastructure
Kidney - enzymology
Kidney - ultrastructure
Lysosomes - enzymology
Male
Microscopy, Electron
Rats
Renin - metabolism
Vertebrates: endocrinology
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Summary:Mature juxtaglomerular epithelioid cell secretory granules of the rat exhibit both renin- and cathepsin B-like immunoreactivity. On the basis of the coexistence with renin at a pH which, according to previous experiments, is probably in the range of that in lysosomes, cathepsin B is suggested to be involved in the activation of renin prior to secretion.
ISSN:0301-5564
1432-119X
DOI:10.1007/BF00495138